GAD1/GAD67 Antibody

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: ICC/IF, IHC-Fr, WB.

Showing Publication 1 - 1 of 1.

Publication using NBP1-06989	Applications	Species
Mouton-Liger F, Sahun I, Collin T et al. Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: Implications for Down syndrome. Neurobiol Dis 2014-03-01 [PMID: 24291518] (IHC-Fr, ICC/IF, WB, Mouse)	IHC-Fr, ICC/IF, WB	Mouse

Images	Ratings	Applications	Species	Date	Details
	1 reviewed by: Filip Dybowski	ICC	Mouse	06/08/2023	View Summary Application Immunocytochemistry Sample Tested Mouse brain 4% PFA fixed 40um sections Species Mouse Lot 28 Comments Comments ***Bio-Techne Response: Thank you for reviewing our product. We are sorry to hear that this product did not perform as expected. We have been in touch with the customer to resolve this issue according to our Product Guarantee and to the customer’s satisfaction.*** Overnight incubation of free-floating sections in primary diluted in TBS-T (with NDS). Secondary incubated for 2 hours.

Array NBP1-06989

• GAD1/GAD67 Antibodies
• GAD1/GAD67 ELISA Kits
• GAD1/GAD67 Lysate
• GAD1/GAD67 Proteins