GAD1/GAD67 Antibody (OTI3G9)

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Zebrafish.

We have publications tested in 2 applications: PEP-ELISA, WB.

Showing Publications 1 - 2 of 2.

Publications using NBP1-48272	Applications	Species
Budaszewski Pinto C, de SA Couto-Pereira N, Kawa Odorcyk F et al. Effects of acute seizures on cell proliferation, synaptic plasticity and long-term behavior in adult zebrafish Brain research 2021-04-01 [PMID: 33539794] (WB, Zebrafish)	WB	Zebrafish
Agca S, Houen G, Trier Nh. Characterization of continuous B-cell epitopes in the n-terminus of glutamate decarboxylase67 using monoclonal antibodies J. Pept. Sci. 2014-12-01 [PMID: 25358241] (PEP-ELISA, Human) Details: GAD1/GAD67 antibody used for a modified PEP-ELISA on 59 different peptides - overlapping (10 amino acids) 20-mer peptides, covering the complete human GAD67 sequence (Ac. no: Q99259). The antibody was found to show reactivity to linear epitope located at the n-terminal end of GAD67 - amino acids 91- 99 : TETDFSnLF	PEP-ELISA	Human

Array NBP1-48272

• GAD1/GAD67 Antibodies
• GAD1/GAD67 ELISA Kits
• GAD1/GAD67 Lysate
• GAD1/GAD67 Proteins