ERK5/BMK1 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Extracellular signal-regulated kinase 5 (ERK5), also known as big mitogen-activated protein kinase 1 (BMK1) and MAPK7, is activated by a several mechanisms, including receptor tyrosine kinases, G protein-coupled receptors, and osmotic stress. Like ERK1 and ERK2, ERK5 contains the conserved Thr-Glu-Tyr activation motif in its activation loop. Unlike these ERKs, however, ERK5 contains a unique C-terminal domain that regulates its activation and nuclear translocation. ERK5’s upstream MAPK kinase has been identified as MEK5.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: ICC, Western Blot.

Showing Publications 1 - 4 of 4.

Publications using AF2848	Applications	Species
Y Liu, Y Huang, Y Xu, P Qu, M Wang Memantine protects against ischemia/reperfusion-induced brain endothelial permeability IUBMB Life, 2018-03-15;0(0):. 2018-03-15 [PMID: 29542225] (Western Blot, Human)	Western Blot	Human
Emma L. Wilkinson, James E. Sidaway, Michael J. Cross Statin regulated ERK5 stimulates tight junction formation and reduces permeability in human cardiac endothelial cells Journal of Cellular Physiology 2018-01-01 [PMID: 28639275]
Badshah I, Baines D, Dockrell M Erk5 is a mediator to TGFbeta1-induced loss of phenotype and function in human podocytes. Front Pharmacol, 2014-04-21;5(0):71. 2014-04-21 [PMID: 24795631] (ICC, Human)	ICC	Human
Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME TGF-beta activates ERK5 in human renal epithelial cells. Biochem. Biophys. Res. Commun., 2008-06-25;373(3):440-4. 2008-06-25 [PMID: 18588859] (ICC, Human)	ICC	Human

Array AF2848

• ERK5/BMK1 Antibodies
• ERK5/BMK1 Lysates
• ERK5/BMK1 Protein