Home » Endorepellin/Perlecan/Heparan Sulfate Proteoglycan » Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibodies » Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 350]
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Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 350]

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Product Details

Summary
Reactivity Hu, Mu, Po, Bv, Fi, PmSpecies Glossary
Applications Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF
Clone
A7L6
Clonality
Monoclonal
Host
Rat
Conjugate
DyLight 350

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP2-47695AF350
Alexa Fluor 405
NBP2-47695AF405
Alexa Fluor 488
NBP2-47695AF488
Alexa Fluor 532
NBP2-47695AF532
Alexa Fluor 594
NBP2-47695AF594
Alexa Fluor 647
NBP2-47695AF647
Alexa Fluor 700
NBP2-47695AF700
Alexa Fluor 750
NBP2-47695AF750
Allophycocyanin
NBP2-47695APC
Biotin
NBP2-47695B
CoraFluor 1
NBP2-47695CL1
DyLight 405
NBP2-47695V
DyLight 488
NBP2-47695G
DyLight 550
NBP2-47695R
DyLight 594
NBP2-47695DL594
DyLight 650
NBP2-47695C
DyLight 680
NBP2-47695FR
DyLight 755
NBP2-47695IR
FITC
NBP2-47695F
HRP
NBP2-47695H
Janelia Fluor 525
NBP2-47695JF525
Janelia Fluor 549
NBP2-47695JF549
Janelia Fluor 646
NBP2-47695JF646
Janelia Fluor 669
NBP2-47695JF669
PE
NBP2-47695PE
PerCP
NBP2-47695PCP
Unconjugated
NBP2-44448-0.1mg
mFluor Violet 450 SE
NBP2-47695MFV450
mFluor Violet 500 SE
NBP2-47695MFV500
mFluor Violet 610 SE
NBP2-47695MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP2-44448-0.1mg
Azide and BSA Free
NBP2-47695-0.1mg
IHC-Prediluted
NBP2-48243
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Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 350] Summary

Description
This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
Immunogen
Murine EHS laminin preparation
Localization
Basement membrane
Specificity
This monoclonal antibody specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecans strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
HSPG2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Use in Human reported in scientific literature (PMID:34228647)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 350]

  • basement membrane-specific heparan sulfate proteoglycan core protein
  • endorepellin (domain V region)
  • heparan sulfate proteoglycan 2
  • Heparan Sulfate Proteoglycan
  • HSPG
  • perlecan proteoglycan
  • perlecan
  • PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
  • PRCAN
  • SJA
  • SJS
  • SJS1

Background

Perlecan is an extracellular matrix proteoglycan. It has a large core protein of 400-450 kDa and is often produced with heparan sulfate side chains. Perlecan is found in basement membranes where it contributes to the permeability characteristics, serves as a substrate for vascular cells and binds growth factors involved in vascular remodeling (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Endorepellin/Perlecan/ ...
NBP2-47695UV
Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (A7L6) [DyLight 350]
Species: Hu, Mu, Po, Bv, Fi, Pm
Applications: Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol HSPG2