DYRK1A Antibody (7D10)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: IF/IHC, KO, WB.

Showing Publications 1 - 10 of 66. Show All 66 Publications. Collapse Publications.

Publications using H00001859-M01	Applications	Species
Joung J, Ma S, Tay T et al. A transcription factor atlas of directed differentiation Cell 2023-01-05 [PMID: 36608654] (KO, WB, Human) Details: Dilution used 1:250, see supplemental figure S5	KO, WB	Human
IIsabel P, Elisa B, Cristina S et al. Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome. Sci Rep. 2022-11-19 [PMID: 36402907]
Delabar JM, Latour A, Noll C et al. One-carbon cycle alterations induced by Dyrk1a dosage. Molecular Genetics and Metabolism Reports Nov 12 2014
Grau C, Arato K, Fernandez-Fernandez JM et al. DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors. Front Oct 17 2014
Paige M, Justin T, Silvia A et al. Genetic Mapping of APP and Amyloid-? Biology Modulation by Trisomy 21. J Neurosci. 2022-08-17 [PMID: 35835549]
Laura H, Faith P, Megan S et al. Sexually dimorphic DYRK1A overexpression on postnatal day 15 in the Ts65Dn mouse model of Down syndrome: Effects of pharmacological targeting on behavioral phenotypes. Pharmacol Biochem Behav. 2022-05-14 [PMID: 35576991]
David W, James M, Pawel D et al. Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B. J Med Chem. 2021-06-18 [PMID: 34143631]
Chi-Hyun P, Goeun K, Yuri L et al. A natural compound harmine decreases melanin synthesis through regulation of the DYRK1A/NFATC3 pathway. J Dermatol Sci. 2021-05-15 [PMID: 34030962]
Csaba W, Melinda S, Attila P et al. Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors. J Med Chem. 2021-05-12 [PMID: 33975430]
Ye L, Eunju I, Minju H et al. Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation. J Biol Chem. 2021-01-08 [PMID: 33380426]
Marta F, Yu G, Nadim K et al. Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Mol Neurobiol. 2020-06-05 [PMID: 32504418]
Roewenstrunk J, Di Vona C, Chen J et al. A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response. Sci Rep. 2019-04-12 [PMID: 30979931]
Souchet B, Audrain M, Billard JM et al. Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice. Acta Neuropathol Commun 2019-03-18 [PMID: 30885273]
Kyei GB, Meng S, Ramani R et al. Splicing Factor 3B Subunit 1 Interacts with HIV Tat and Plays a Role in Viral Transcription and Reactivation from Latency. MBio 2018-11-06 [PMID: 30401776]
Baloula V, Fructuoso M, Kassis N et al. Homocysteine-lowering gene therapy rescues signaling pathways in brain of mice with intermediate hyperhomocysteinemia. Redox Biol 2018-08-25 [PMID: 30172984]
Parras A, Anta H, Santos-Galindo M et al. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 2018-08-15 [PMID: 30111840]
Latour A, Gu Y, Kassis N et al. LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice. Mol Neurobiol 2018-05-30 [PMID: 29850989]
Garcia-Cerro S, Vidal V, Lantigua S et al. Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene. Neurobiol Dis 2017-12-05 [PMID: 29221819]
Audrain M, Souchet B, Alves S et al. ?APP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimers Disease. Cereb Cortex. 2018-11-01 [PMID: 29048465]
Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia. Latour A, Salameh S, Carbonne C et al. Mol Genet Metab Rep [PMID: 28649528] (WB, Mouse)	WB	Mouse
Janel N, Alexopoulos P, Badel A et al. Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease. Transl Psychiatry 2017-06-20 [PMID: 28632203]
London J, Rouch C, Bui LC et al. Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues. Mol Neurobiol 2017-05-25 [PMID: 28540658]
Delabar JM, Latour A, Noll C et al. One-carbon cycle alterations induced by Dyrk1a dosage. Molecular Genetics and Metabolism 2014-01-01 [PMID: 27896129]
Rabaneda LG, Geribaldi-Doldan N, Murillo-Carretero M et al. Altered regulation of the Spry2/Dyrk1A/PP2A triad by homocysteine impairs neural progenitor cell proliferation. Biochim Biophys Acta 2016-12-01 [PMID: 27686255]
Glenewinkel F, Cohen MJ, King CR et al. The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep 2016-06-16 [PMID: 27307198]
Booiman T, Loukachov VV, van Dort KA et al. DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner. PLoS One 2015-12-07 [PMID: 26641855] (WB)	WB
Kurabayashi N, Nguyen MD, Sanada K. DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse model. EMBO Rep. 2015-09-15 [PMID: 26373433]
Stringer M, Abeysekera I, Dria KJ et al. Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model. Pharmacol Biochem Behav. 2015-09-10 [PMID: 26363314]
Joshua D, Blazek, Irushi Abeysekera, Jiliang Li and Randall J, Roper. Rescue of the abnormal skeletal phenotype in Ts65Dn Down syndrome mice using genetic and therapeutic modulation of trisomic Dyrk1a. Hum Mol Genet. 2015-07-23 [PMID: 26206885]
Najas S, Arranz J, Lochhead PA et al. DYRK1A-mediated Cyclin D1 Degradation in Neural Stem Cells Contributes to the Neurogenic Cortical Defects in Down Syndrome. EBioMedicine. 2015-01-17 [PMID: 26137553]
Thompson BJ, Bhansali R, Diebold L et al. DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3. J Exp Med. 2015-05-25 [PMID: 26008897]
Chiara V, Daniela B, Abul I et al. Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase. Mol Cell. 2015-01-22 [PMID: 25620562]
Grau C, Arato K, Fernandez-Fernandez JM et al. DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors. Front. Cell. Neurosci. 2014-01-01 [PMID: 25368549]
Garcia-Cerro S, Martinez P, Vidal V et al. Overexpression of Dyrk1A Is Implicated in Several Cognitive, Electrophysiological and Neuromorphological Alterations Found in a Mouse Model of Down Syndrome. PLoS One. 2014-09-04 [PMID: 25188425]
Janel N, Sarazin M, Corlier F et al. Plasma DYRK1A as a novel risk factor for Alzheimer's disease. Transl Psychiatry. 2014-08-12 [PMID: 25116835] (WB)	WB
Souchet B, Latour A, Gu Y et al. Molecular Rescue of DYRK1A Overexpression in Cystathionine Beta Synthase-Deficient Mouse Brain by Enriched Environment Combined with Voluntary Exercise. J Mol Neurosci. 2014-05-13 [PMID: 24819931]
Rachdi L, Kariyawasam D, Guez F et al. Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass. Diabetologia. 2014-01-30 [PMID: 24477974]
Thomazeau A, Lassalle O, Iafrati J et al. Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a. J Neurosci. 2014-01-22 [PMID: 24453307]
Hibaoui Y, Grad I, Letourneau A et al. Modelling and rescuing neurodevelopmental defect of Down syndrome using induced pluripotent stem cells from monozygotic twins discordant for trisomy 21. EMBO Mol Med. 2014-01-09 [PMID: 24375627]
Fant X, Durieu E, Chicanne G et al. CLK/DYRK Kinases Inhibitor Leucettine L41 Induces Mtor-dependent Autophagy. Implication for Alzheimers' Disease. Mol Pharmacol. 2013-12-23 [PMID: 24366666]
Pons-Espinal M, Martinez de Lagran M, Dierssen M. Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A. Neurobiol Dis. 2013-08-20 [PMID: 23969234]
Stefos GC, Soppa U, Dierssen M, Becker W. NGF Upregulates the Plasminogen Activation Inhibitor-1 in Neurons via the Calcineurin/NFAT Pathway and the Down Syndrome-Related Proteins DYRK1A and RCAN1 Attenuate This Effect. PLoS One. 2013-06-25 [PMID: 23825664]
Laguna A, Barallobre MJ, Marchena MA et al. Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome. Hum Mol Genet. 2013-03-27 [PMID: 23512985]
Tlili A, Jacobs F, de Koning L et al. Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice. Biochim Biophys Acta. 2013-02-11 [PMID: 23429073]
Arque G, Casanovas A, Dierssen M. Dyrk1A Is Dynamically Expressed on Subsets of Motor Neurons and in the Neuromuscular Junction: Possible Role in Down Syndrome. PLoS One. 2013-01-16 [PMID: 23342120]
Altafaj X, Martin ED, Ortiz-Abalia J et al. Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2013-04-01 [PMID: 23220201] (IF/IHC, Mouse)	IF/IHC	Mouse
Spellman C, Ahmed MM, Dubach D, Gardiner KJ. Expression of trisomic proteins in Down syndrome model systems. Gene. 2012-10-26 [PMID: 23103828]
Guo X, Kesimer M, Tolun G et al. The NAD(+)-dependent protein deacetylase activity of SIRT1 is regulated by its oligomeric status. Sci Rep. 2012-09-07 [PMID: 22962634]
Abekhoukh S, Planque C, Ripoll C et al. Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice. Mol Neurobiol. 2012-08-26 [PMID: 22923366]
Planque C, Dairou J, Noll C et al. Mice Deficient in Cystathionine Beta Synthase Display Increased Dyrk1A and SAHH Activities in Brain. J Mol Neurosci. 2012-06-15 [PMID: 22700376]
Malinge S, Bliss-Moreau M, Kirsammer G et al. Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome. J Clin Invest. 2012-03-01 [PMID: 22354171] (WB)	WB
Guedj F, Pereira PL, Najas S et al. DYRK1A: A master regulatory protein controlling brain growth. Neurobiol Dis. 2012-01-26 [PMID: 22293606]
Park J, Sung JY, Park J et al. Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP. J Cell Sci. 2012-01-16 [PMID: 22250195]
Ahmed MM, Sturgeon X, Ellison M et al. Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome. J Proteome Res. 2012-01-25 [PMID: 22214338]
Kida E, Walus M, Jarzabek K et al. Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals. Neuroscience. 2011-08-19 [PMID: 21878370]
Sheppard O, Plattner F, Rubin A et al. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiol Aging. 2011-08-13 [PMID: 21843906]
Toiber D, Azkona G, Ben-Ari S et al. Engineering DYRK1A over-dosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis. 2010-06-30 [PMID: 20600907]
Guo X, Williams JG, Schug TT, Li X. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem;285(17):13223-32. 2010-04-23 [PMID: 20167603]
Raaf L, Noll C, Cherifi M et al. Hyperhomocysteinemia-induced Dyrk1a downregulation results in cardiomyocyte hypertrophy in rats. Int J Cardiol. 2009-11-09 [PMID: 19906449]
Noll C, Planque C, Ripoll C et al. DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. PLoS One;4(10):e7540. 2009-10-21 [PMID: 19844572]
Lee Y, Ha J, Kim HJ et al. Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis. J Biol Chem;284(48):33343-51. 2009-11-27 [PMID: 19801542]
Scales TM, Lin S, Kraus M, Goold RG, Gordon-Weeks PR. Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. J Cell Sci;122(Pt 14):2424-35. 2009-07-15 [PMID: 19549690]
Guedj F, Sebrie C, Rivals I et al. Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A. PLoS One;4(2):e4606. 2009-01-01 [PMID: 19242551]
Hamelet J, Noll C, Ripoll C et al. Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice. Biochem Biophys Res Commun;378(3):673-7. 2009-01-16 [PMID: 19059382]
Ara S, Alvarez M, Turro S et al. Sprouty2 inhibitory activity on FGF-signaling is modulated by the protein kinase DYRK1A. Mol Cell Biol;28(19):5899-911. 2008-10-01 [PMID: 18678649]
Toiber D, Azkona G, Ben-Ari S et al. Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations. Neurobiol Dis. 2010-06-30 [PMID: 2060090]
Show All 66 Publications. Collapse Publications.

Array H00001859-M01

• DYRK1A Antibodies
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