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Dopamine beta-Hydroxylase Antibody

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Orthogonal Strategies: Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Analysis in human adrenal gland and testis tissues. Corresponding Dopamine beta-Hydroxylase RNA-seq data are ...read more
Independent Antibodies: Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Staining of human adrenal gland, kidney, lower gastrointestinal and testis using Anti-Dopamine ...read more
Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Staining of human testis shows no positivity in cells in seminiferous ducts as expected.
Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Staining of human adrenal gland shows strong cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Staining of human colon shows strong cytoplasmic positivity in peripheral ganglion.
Immunohistochemistry-Paraffin: Dopamine beta-Hydroxylase Antibody [NBP2-55677] - Staining of human kidney shows no weak positivity in cells in tubules as expected.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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Dopamine beta-Hydroxylase Antibody Summary

Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: VQRTPEGLTLLFKRPFGTCDPKDYLIEDGTVHLVYGILEEPFRSLEAINGSGLQMGLQRVQLLKPNIPEPELPSDACTMEVQAPNIQIPSQETTYWCYIKELPKGFSRHHIIKYEPIVTKGN
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DBH
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
Dopamine beta-Hydroxylase Recombinant Protein Antigen (NBP2-55677PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for Dopamine beta-Hydroxylase Antibody

  • DBH
  • DBM
  • dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  • Dopamine betaHydroxylase
  • Dopamine beta-Hydroxylase
  • Dopamine beta-monooxygenase
  • DOPBHY
  • EC 1.14.17.1

Background

Dopamine beta-hydroxylase belongs to the copper type II, ascorbate-dependent monooxygenase family and catalyzes the oxidative hydroxylation of dopamine to noradrenaline. It is almost exclusively located in the adrenal medulla and the synaptic vesicles of postganglionic sympathetic neurons being expressed in noradrenergic and adrenergic neurons. DBH serves as a marker of noradrenergic cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DBH