CPT1A Antibody

The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 2 applications: IHC-P, WB.

Showing Publications 1 - 9 of 9.

Publications using NB100-53791	Applications	Species
Ferrarini F, Zulato E, Moro M et al. Metabolic classification of non-small cell lung cancer patient-derived xenografts by a digital pathology approach: A pilot study Frontiers in oncology 2023-02-28 [PMID: 36925926] (IHC-P, Human)	IHC-P	Human
Yang Q, Sun S, Liu W et al. Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice Biochemical and Biophysical Research Communications 2020-02-01 [PMID: 32122652] (WB, Mouse)	WB	Mouse
Zhao L, Niu J, Lin H et al. Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases EBioMedicine 2019-10-17 [PMID: 31631034] (WB, Mouse)	WB	Mouse
Morkholt AS, Trabjerg MS, Oklinski MKE et al. CPT1A plays a key role in the development and treatment of multiple sclerosis and experimental autoimmune encephalomyelitis Sci Rep 2019-09-16 [PMID: 31527712] (WB, Mouse)	WB	Mouse
Zhang ZF, Fan SH, Zheng YL et al. Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice. Biochem. Pharmacol. 2014-09-01 [PMID: 25026599] (WB, Mouse) Details: CPT1A/carnitine palmitoyltransferase 1A antibody used for WB on lysates of liver tissues from mouse fed or not with high fat diet and/or treated with Troxerutin (PubChem CID 9896814) or EX527 (PubChem CID 5113032)- loading amount of lysate 50 ug, membrane blocking with 5% non-fat milk in 0.1% Tween-20/TBS, ON 4C primary incubation (Fig 8A).	WB	Mouse
Goedeke L, Vales-Lara FM, Fenstermaker M et al. A Regulatory Role for MicroRNA 33(Asterisk) in Controlling Lipid Metabolism Gene Expression. Mol Cell Biol 2013-06-01 [PMID: 23547260] (WB, Human)	WB	Human
Jin K, Norris K, Vaziri ND. Dysregulation of hepatic fatty acid metabolism in chronic kidney disease Nephrol Dial Transplant 2012-10-08 [PMID: 23045433] (WB, Rat)	WB	Rat
Rayner KJ, Esau CC, Hussain FN et al. Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides. Nature;478(7369):404-407. 2011-10-20 [PMID: 22012398]
Pocai A, Lam TK, Obici S et al. Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats. J Clin Invest 2006-04-01 [PMID: 16528412]

Array NB100-53791

• CPT1A Antibodies
• CPT1A ELISA Kits
• CPT1A Lysates
• CPT1A Proteins