CD27 Ligand/TNFSF7/CD70 Antibody (BU69) [Janelia Fluor® 549]

Clone BU69 was used by HLDA to establish CD designation.

Human WM-1 (Waldenstrom s macroglobulinemia) cell line

Cell Surface

Activated T- & B-Lymphocyte Marker

It recognizes a protein of 30kDa, identified as CD70. It is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T- and B-lymphocytes. It induces proliferation of co-stimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis. This monoclonal antibody blocks the interaction between CD27 and CD70, and has been shown to inhibit T cell proliferation induced by dendritic cells.

IgG1 Kappa

Monoclonal

Mouse

CD70

Protein A or G purified

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Optimal dilution of this antibody should be experimentally determined.