alpha-Galactosidase A/GLA Antibody (1029705) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human alpha -Galactosidase A is a homodimeric glycoprotein that can release terminal alpha -galactosyl moieties from glycolipids and glycoproteins and catalyze the hydrolysis of melibiose into galactose and glucose (1). It is a lysosomal enzyme and is responsible for degradation of glycolipid globotriaosylceramide (Gb3) (Gal alpha 1‑4Gal beta 1‑4Glc beta ‑ceramide). Mutations in this gene cause Fabry disease, an X-linked hereditary lysosomal storage disease with the accumulation of Gb3 in the walls of small blood vessels, nerves, dorsal root ganglia, renal glomerular and tubular epithelial cells, and cardiomyocytes (2, 3). Inability to prevent the glycosphingolipid deposition can cause hypertension, strokes, heart attack and progressive renal failure (4). Current treatment for Fabry disease is enzyme replacement therapy using intravenously delivered recombinant alpha -Galactosidase A (5, 6).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB6146

• alpha-Galactosidase A/GLA Antibodies
• alpha-Galactosidase A/GLA Antibody Pair
• alpha-Galactosidase A/GLA ELISA Kits
• alpha-Galactosidase A/GLA Lysate
• alpha-Galactosidase A/GLA Proteins
• alpha-Galactosidase A/GLA Proteins and Enzyme