Mouse Complement Component C5a DuoSet ELISA, 15 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Mouse Complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as Anaphylatoxins. C5a is a 77 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 alpha -chain. Mouse C5a has four alpha -helices, plus three intrachain disulfide bonds that create a triple loop structure. In serum, proteolytic processing removes the C-terminal arginine, creating a low activity C5a desArg77 molecule. Mouse C5a shares 60% and 82% aa sequence identity to human and rat C5a, respectively. C5a binds to a signaling G-protein coupled receptor (GPCR) (C5aR/CD88), inducing neutrophil chemotaxis and endothelial cell activation. It also triggers an oxidative burst in macrophages and neutrophils, and induces release of histamine in basophils and mast cells. Alternatively, it may also bind to a nonsignaling GPCR termed C5L2 whose function is yet to be determined.

We have publications tested in 2 confirmed species: Mouse, Rat.

Showing Publications 1 - 10 of 41. Show All 41 Publications. Collapse Publications.

Publications using DY2150	Applications	Species
Li, Y;Jacques, S;Gaikwad, H;Wang, G;Banda, NK;Holers, VM;Scheinman, RI;Tomlinson, S;Moghimi, SM;Simberg, D; Inhibition of acute complement responses towards bolus-injected nanoparticles using targeted short-circulating regulatory proteins Nature nanotechnology 2023-10-05 [PMID: 37798566] (Mouse)		Mouse
NC Teske, JY Engelen-Le, S Dyckhoff-S, HW Pfister, M Klein, D van de Bee, CK Kirschning, U Koedel, MC Brouwer The role of plasminogen activator inhibitor-2 in pneumococcal meningitis Acta neuropathologica communications, 2022-10-29;10(1):155. 2022-10-29 [PMID: 36309755] (Mouse)		Mouse
G Arora, GE Lynn, X Tang, CE Rosen, D Hoornstra, A Sajid, JW Hovius, NW Palm, AM Ring, E Fikrig CD55 Facilitates Immune Evasion by Borrelia crocidurae, an Agent of Relapsing Fever MBio, 2022-08-29;0(0):e0116122. 2022-08-29 [PMID: 36036625] (Mouse)		Mouse
M Llorián-Sa, EM Byrne, M Szczepan, K Little, M Chen, H Xu Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells Journal of Neuroinflammation, 2022-07-14;19(1):182. 2022-07-14 [PMID: 35831910] (Mouse)		Mouse
K Carvalho, ND Schartz, G Balderrama, HY Liang, SH Chu, P Selvan, A Gomez-Arbo, TJ Petrisko, MI Fonseca, A Mortazavi, AJ Tenner Modulation of C5a-C5aR1 signaling alters the dynamics of AD progression Journal of Neuroinflammation, 2022-07-11;19(1):178. 2022-07-11 [PMID: 35820938] (Mouse)		Mouse
P Ding, Y Xu, L Li, X Lv, L Li, J Chen, D Zhou, X Wang, Q Wang, W Zhang, T Liao, QH Ji, QY Lei, W Hu Intracellular complement C5a/C5aR1 stabilizes beta-catenin to promote colorectal tumorigenesis Cell Reports, 2022-05-31;39(9):110851. 2022-05-31 [PMID: 35649359] (Mouse)		Mouse
Y Tachida, S Miura, Y Muto, H Takuwa, N Sahara, A Shindo, Y Matsuba, T Saito, N Taniguchi, Y Kawaguchi, H Tomimoto, T Saido, S Kitazume Endothelial expression of human amyloid precursor protein leads to amyloid beta in the blood and induces cerebral amyloid angiopathy in knock-in mice The Journal of Biological Chemistry, 2022-03-31;0(0):101880. 2022-03-31 [PMID: 35367207] (Mouse)		Mouse
AK Bongoni, IB Vikstrom, JL McRae, EJ Salvaris, N Fisicaro, MJ Pearse, S Wymann, T Rowe, AB Morelli, MP Hardy, PJ Cowan A potent truncated form of human soluble CR1 is protective in a mouse model of renal ischemia-reperfusion injury Scientific Reports, 2021-11-08;11(1):21873. 2021-11-08 [PMID: 34750424] (Mouse)		Mouse
TR Mikuls, R Gaurav, GM Thiele, BR England, MG Wolfe, BP Shaw, KL Bailey, TA Wyatt, AJ Nelson, MJ Duryee, CD Hunter, D Wang, DJ Romberger, DP Ascherman, JA Poole The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease International immunopharmacology, 2021-08-27;100(0):108069. 2021-08-27 [PMID: 34461491] (Mouse)		Mouse
A Doni, R Parente, I Laface, E Magrini, C Cunha, FS Colombo, JF Lacerda, A Campos, SN Mapelli, F Petroni, R Porte, T Schorn, A Inforzato, T Mercier, K Lagrou, J Maertens, JD Lambris, B Bottazzi, C Garlanda, M Botto, A Carvalho, A Mantovani Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus Nature Communications, 2021-06-18;12(1):3739. 2021-06-18 [PMID: 34145258] (Mouse)		Mouse
SA Appiah, CL Foxx, D Langgartne, A Palmer, CA Zambrano, S Braumüller, EJ Schaefer, U Wachter, BL Elam, P Radermache, CE Stamper, JD Heinze, SN Salazar, AK Luthens, AL Arnold, SO Reber, M Huber-Lang, CA Lowry, R Halbgebaue Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock Scientific Reports, 2021-03-23;11(1):6665. 2021-03-23 [PMID: 33758228] (Mouse)		Mouse
RS Aquino, A Hayashida, PW Park Host syndecan-1 promotes listeriosis by inhibiting intravascular neutrophil extracellular traps PLoS Pathog., 2020-05-26;16(5):e1008497. 2020-05-26 [PMID: 32453780] (Mouse)		Mouse
FH Brennan, T Jogia, ER Gillespie, LV Blomster, XX Li, B Nowlan, GM Williams, E Jacobson, GW Osborne, FA Meunier, SM Taylor, KE Campbell, KP MacDonald, JP Levesque, TM Woodruff, MJ Ruitenberg Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2 JCI Insight, 2019-05-02;4(9):. 2019-05-02 [PMID: 31045582] (Mouse)		Mouse
V Escamilla-, A Solorio-Ro, M Uribe-Ramí, O Lozano, S Lucas, A Chagolla-L, R Winkler, A De Vizcaya Plasma protein adsorption on Fe3O4-PEG nanoparticles activates the complement system and induces an inflammatory response Int J Nanomedicine, 2019-03-25;14(0):2055-2067. 2019-03-25 [PMID: 30988608] (Mouse)		Mouse
C Hu, L Li, P Ding, L Li, X Ge, L Zheng, X Wang, J Wang, W Zhang, N Wang, H Gu, F Zhong, M Xu, R Rong, T Zhu, W Hu Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling J. Immunol., 2018-11-14;0(0):. 2018-11-14 [PMID: 30429287] (Mouse)		Mouse
F Fattahi, MW Russell, EA Malan, M Parlett, E Abe, FS Zetoune, PA Ward Harmful Roles of TLR3 and TLR9 in Cardiac Dysfunction Developing during Polymicrobial Sepsis Biomed Res Int, 2018-09-30;2018(0):4302726. 2018-09-30 [PMID: 30364002] (Mouse)		Mouse
B Wang, H Xu, J Li, HM Gao, YH Xing, Z Lin, HJ Li, YQ Wang, SH Cao Complement depletion with cobra venom factor alleviates acute hepatic injury induced by ischemia?reperfusion Mol Med Rep, 2018-09-14;0(0):. 2018-09-14 [PMID: 30221740] (Rat)		Rat
R Spirig, IK Campbell, S Koernig, CG Chen, BJB Lewis, R Butcher, I Muir, S Taylor, J Chia, D Leong, J Simmonds, P Scotney, P Schmidt, L Fabri, A Hofmann, M Jordi, MO Spycher, S Cattepoel, J Brasseit, C Panousis, T Rowe, DR Branch, A Baz Morell, F Käsermann, AW Zuercher rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and Fc?Rs J. Immunol., 2018-03-12;0(0):. 2018-03-12 [PMID: 29531170] (Mouse)		Mouse
JD Boehme, S Stegemann-, A Autengrube, N Peters, J Wissing, L Jänsch, A Jeron, D Bruder Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance Sci Rep, 2017-07-10;7(1):4972. 2017-07-10 [PMID: 28694492] (Mouse)		Mouse
Y Wang, P Lai, X Chen, C He, X Huang, S Geng, C Luo, S Wu, W Ling, L Zhong, Z Lu, P Li, J Weng, X Du Attenuation of cGVHD by C5a/C5aR blockade is associated with increased frequency of Treg Sci Rep, 2017-06-15;7(1):3603. 2017-06-15 [PMID: 28620195] (Mouse)		Mouse
S Bergdolt, A Kovtun, Y Hägele, A Liedert, T Schinke, M Amling, M Huber-Lang, A Ignatius Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing PLoS ONE, 2017-06-14;12(6):e0179512. 2017-06-14 [PMID: 28614388] (Mouse)		Mouse
JH Sheen, MG Strainic, J Liu, W Zhang, Z Yi, ME Medof, PS Heeger TLR-Induced Murine Dendritic Cell (DC) Activation Requires DC-Intrinsic Complement J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539427] (Mouse)		Mouse
AK Bongoni, B Lu, EJ Salvaris, V Roberts, D Fang, JL McRae, N Fisicaro, KM Dwyer, PJ Cowan Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice J. Immunol., 2017-05-12;0(0):. 2017-05-12 [PMID: 28500075] (Mouse)		Mouse
LG Coulthard, OA Hawksworth, R Li, A Balachandr, JD Lee, F Sepehrband, N Kurniawan, A Jeanes, DG Simmons, E Wolvetang, TM Woodruff Complement C5aR1 Signaling Promotes Polarization and Proliferation of Embryonic Neural Progenitor Cells through PKC? J. Neurosci., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455369] (Mouse)		Mouse
KM Cunnion, NK Krishna, HK Pallera, A Pineros-Fe, MG Rivera, PS Hair, BP Lassiter, R Huyck, MA Clements, AF Hood, GT Rodeheaver, PS Cottler, JL Nadler, AD Dobrian Complement Activation and STAT4 Expression Are Associated with Early Inflammation in Diabetic Wounds PLoS ONE, 2017-01-20;12(1):e0170500. 2017-01-20 [PMID: 28107529] (Mouse)		Mouse
High-fat diet-induced complement activation mediates intestinal inflammation and neoplasia, independent of obesity Mol Cancer Res, 2016-08-17;0(0):. 2016-08-17 [PMID: 27535705] (Mouse)		Mouse
The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1 J Neurosci, 2016-05-04;36(18):5055-70. 2016-05-04 [PMID: 27147658] (Mouse)		Mouse
Sun D, Zhang M, Liu G, Wu H, Zhu X, Zhou H, Shi M Real-Time Imaging of Interactions of Neutrophils with Cryptococcus neoformans Demonstrates a Crucial Role of Complement C5a-C5aR Signaling. Infect Immun, 2015-10-26;84(1):216-29. 2015-10-26 [PMID: 26502909] (Mouse)		Mouse
Brennan F, Gordon R, Lao H, Biggins P, Taylor S, Franklin R, Woodruff T, Ruitenberg M The Complement Receptor C5aR Controls Acute Inflammation and Astrogliosis following Spinal Cord Injury. J Neurosci, 2015-04-22;35(16):6517-31. 2015-04-22 [PMID: 25904802] (Mouse)		Mouse
Chou C, Lai S, Ho C, Lin W, Chen C, Lee P, Peng F, Kuo S, Wu S, Lai H Lysophosphatidic acid alters the expression profiles of angiogenic factors, cytokines, and chemokines in mouse liver sinusoidal endothelial cells. PLoS ONE, 2015-03-30;10(3):e0122060. 2015-03-30 [PMID: 25822713] (Mouse)		Mouse
Price P, Banki Z, Scheideler A, Stoiber H, Verschoor A, Sutter G, Lehmann M Complement component C5 recruits neutrophils in the absence of C3 during respiratory infection with modified vaccinia virus Ankara. J Immunol, 2014-12-29;194(3):1164-8. 2014-12-29 [PMID: 25548218] (Mouse)		Mouse
Sharif O, Gawish R, Warszawska J, Martins R, Lakovits K, Hladik A, Doninger B, Brunner J, Korosec A, Schwarzenbacher R, Berg T, Kralovics R, Colinge J, Mesteri I, Gilfillan S, Salmaggi A, Verschoor A, Colonna M, Knapp S The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia. PLoS Pathog, 2014-06-12;10(6):e1004167. 2014-06-12 [PMID: 24945405] (Mouse)		Mouse
Ehrnthaller , Christia, Huber-Lang , Markus, Nilsson , Per, Bindl , Ronny, Redeker , Simon, Recknagel , Stefan, Rapp , Anna, Mollnes , Tom, Amling , Michael, Gebhard , Florian, Ignatius , Anita Complement C3 and C5 deficiency affects fracture healing. PLoS ONE, 2013-11-18;8(11):e81341. 2013-11-18 [PMID: 24260573] (Mouse)		Mouse
Gauvreau D, Gupta A, Fisette A, Tom F, Cianflone K Deficiency of C5L2 increases macrophage infiltration and alters adipose tissue function in mice. PLoS ONE, 2013-04-22;8(4):e60795. 2013-04-22 [PMID: 23630572] (Mouse)		Mouse
Kwan WH, Hashimoto D, Paz-Artal E Antigen-presenting cell-derived complement modulates graft-versus-host disease. J. Clin. Invest., 2012-05-15;122(6):2234-8. 2012-05-15 [PMID: 22585573] (Mouse)		Mouse
Jang JH, Liang D, Kido K Increased local concentration of complement C5a contributes to incisional pain in mice. J Neuroinflammation, 2011-07-07;8(0):80. 2011-07-07 [PMID: 21736743] (Mouse)		Mouse
Vieyra M, Leisman S, Raedler H, Kwan WH, Yang M, Strainic MG, Medof ME, Heeger PS Complement regulates CD4 T-cell help to CD8 T cells required for murine allograft rejection. Am. J. Pathol., 2011-06-23;179(2):766-74. 2011-06-23 [PMID: 21704012] (Mouse)		Mouse
O'Brien KB, Morrison TE, Dundore DY A protective role for complement C3 protein during pandemic 2009 H1N1 and H5N1 influenza A virus infection. PLoS ONE, 2011-03-09;6(3):e17377. 2011-03-09 [PMID: 21408070] (Mouse)		Mouse
Heimbach L, Li Z, Berkowitz P The C5a Receptor on Mast Cells Is Critical for the Autoimmune Skin-blistering Disease Bullous Pemphigoid. J. Biol. Chem., 2011-03-10;286(17):15003-9. 2011-03-10 [PMID: 21393236] (Mouse)		Mouse
Dahlke K, Wrann CD, Sommerfeld O, Sossdorf M, Recknagel P, Sachse S, Winter SW, Klos A, Stahl GL, Ma YX, Claus RA, Reinhart K, Bauer M, Riedemann NC Distinct Different Contributions of the Alternative and Classical Complement Activation Pathway for the Innate Host Response during Sepsis. J. Immunol., 2011-01-24;186(5):3066-3075. 2011-01-24 [PMID: 21263075] (Mouse)		Mouse
Subramaniam KS, Datta K, Quintero E, Manix C, Marks MS, Pirofski LA The absence of serum IgM enhances the susceptibility of mice to pulmonary challenge with Cryptococcus neoformans. J. Immunol., 2010-04-19;184(10):5755-67. 2010-04-19 [PMID: 20404271] (Mouse)		Mouse
Show All 41 Publications. Collapse Publications.

Array DY2150

• Complement Component C5a Antibodies
• Complement Component C5a ELISA Kits
• Complement Component C5a Protein
• Complement Component C5a Proteins and Enzymes
• Complement Component C5a ELISAs