VEGF-C Products

Description

Vascular endothelial growth factors (VEGFs), also known as vasculotropins, are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate the proliferation of endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. The mitogenic activity of VEGFs appears to be mediated by specific VEGF receptors. The target cell specificity of VEGF is restricted to vascular endothelial cells. Vascular Endothelial Growth Factor C (VEGFC) is a member of the VEGF subfamily of PDGF-related growth factors. It is the ligand for Flt4 (VEGFR3) and KDR (VEGFR2). VEGFC binds Flt4 and induces tyrosine autophosphorylation of VEGFR3 and VEGFR2. VEGFC also stimulates the migration of bovine capillary endothelial cells in collagen gel. It is a specific growth factor for the lymphatic vascular system and mediates lymphangiogenesis. VEGFC is abundantly expressed in heart and skeletal muscle. Other tissues such as lung and kidney also express VEGFC. The human VEGFC gene is located on chromosome 4q34.

Bioinformatics

Entrez	114111 Rat 22341 Mouse 7424 Human
Uniprot	ABM85407.1 Human NP_005420 Human O35757 Rat P49767 Human Q6FH59 Human
Product By Gene ID	7424
Alternate Names	Flt4 ligand Flt4-L vascular endothelial growth factor C Vascular endothelial growth factor-related protein VEGF-C VRPFLT4 ligand DHM

Research Areas for VEGF-C

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
HIF Target Genes
Hypoxia