UHRF1 Products

Description

UHRF1 encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	29128 Human
Uniprot	NM_001048201 Human NP_037414 Human Q96T88 Human
Product By Gene ID	29128
Alternate Names	E3 ubiquitin-protein ligase UHRF1 EC 6.3.2 EC 6.3.2.- FLJ21925 hNP95 huNp95 HuNp95 ICBP90NP95 Inverted CCAAT box-binding protein of 90 kDa Np95 Nuclear protein 95 Nuclear zinc finger protein Np95 RING finger protein 106 RNF106MGC138707 Transcription factor ICBP90 Ubiquitin-like PHD and RING finger domain-containing protein 1 ubiquitin-like with PHD and ring finger domains 1 ubiquitin-like, containing PHD and RING finger domains, 1 Ubiquitin-like-containing PHD and RING finger domains protein 1

Research Areas for UHRF1

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DNA Repair
Zinc Finger

Related UHRF1 Blog Posts

Check out the latest blog posts on UHRF1.

Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation By Jamshed Arslan, Pharm. D., PhD. DNA methylation represses transcription of many genes, including tumor suppressor genes. A protein called UHRF1 recruits DNA methyltransferases (DNMTs) to establish and maintain DNA...    Read more.

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