TMEFF2(transmembrane protein with EGF-like and two follistatin-like domains 2), a gene encoding a plasma membrane protein with two follistatin-like domains and one epidermal growth factor-like domain, had limited normal tissue distribution and was highly overexpressed in prostate cancer. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. Clone J4B6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TMEFF2 protein.
![Binding Activity TMEFF2/Tomoregulin-2 [Unconjugated]](http://images.novusbio.com/fullsize2/11107-tf_recombinant-human-tmeff2-tomoregulin-2-his-tag-protein-cf-binding-activity-182202295010.jpg)
![SDS-PAGE TMEFF2/Tomoregulin-2 [Unconjugated]](http://images.novusbio.com/fullsize2/11204-tf_recombinant-mouse-tmeff2-tomoregulin-2-fc-protein-cf-sds-page-58202294922.jpg)
![SDS-PAGE TMEFF2/Tomoregulin-2 [Unconjugated]](http://images.novusbio.com/fullsize2/11107-tf_recombinant-human-tmeff2-tomoregulin-2-his-tag-protein-cf-sds-page-182202295535.jpg)