Recombinant Mouse TMEFF2/Tomoregulin-2 Fc Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The transmembrane protein with an EGF-like and two Follistatin-like domains 2 (TMEFF2) encodes a 374 residue long single polypeptide, type-I transmembrane proteoglycan. It is also known as HPP1, tomoregulin (TR), transmembrane protein TENB2, cancer/testis antigen family 120, member 2 (CT120.2), and transmembrane protein containing EGF and follistatin domains (TPEF). TMEFF2 amino acid sequences are 98.9% identical for human and mouse orthologs (1). The differential methylation of TMEFF2 can be related to the response to therapy and survival outcomes of the stages of cancers such as breast, prostate, lung, bladder, colon and rectal, gallbladder, renal, oesophageal, cardiac, stomach/gastric, ovarian, multiple myeloma, glioblastoma, and mesothelioma. The range of tissue expression of TMEFF2 functions as a possible biomarker and/or therapeutic target (1). Studies showed that TMEFF2 binds and inhibits PDGF-AA (2,3). It also inhibits the proliferation of DU145 and PC3 prostate cancer cell lines (4). The amyloid-b protein, its precursor AbPP, and amyloid- b proteins AbPOs also binds TMEFF2 suggesting a neuroprotective role on Alzheimer's disease (5). TMEFF2 diverse function includes metabolism, embryonic development, cytoskeletal binding, extracellular matrix binding, chromatin binding and interaction of RNA polymerase II with DNA (6), neuronal development (7).

Array 11204-TF

• TMEFF2/Tomoregulin-2 Antibodies
• TMEFF2/Tomoregulin-2 Lysate
• TMEFF2/Tomoregulin-2 Protein
• TMEFF2/Tomoregulin-2 Proteins and Enzymes