SAFB Products

Description

SAFB encodes a DNA-binding protein that has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor. This gene is a candidate gene for breast tumorigenesis.

Bioinformatics

Entrez	224903 Mouse 6294 Human
Uniprot	NP_002958 Human NP_002958.2 Human
Product By Gene ID	6294
Alternate Names	glutathione S-transferase fusion protein HAP heat-shock protein (HSP27) estrogen response element and TATA box-bindingprotein HETDKFZp779C1727 Hsp27 ERE-TATA binding protein HSP27 ERE-TATA-binding protein HSP27 estrogen response element-TATA box-binding protein SAF-B SAF-B1 SAFB1SAB-B1 scaffold attachment factor B scaffold attachment factor B1

Research Areas for SAFB

Find related products by research area and learn more about each of the different research areas below.

DNA Repair