RUVBL1 Products

Description

Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex

Bioinformatics

Entrez	8607 Human
Uniprot	AAH02993 Human NP_003698 Human Q9Y265 Human
Product By Gene ID	8607
Alternate Names	49 kDa TATA box-binding protein-interacting protein 54 kDa erythrocyte cytosolic protein EC 3.6.1 EC 3.6.4.12,49 kDa TBP-interacting protein ECP54 INO80 complex subunit H INO80HTIP49A NMP 238 NMP238ECP-54 Nuclear matrix protein 238 Pontin 52 PONTIN Pontin52 RuvB (E coli homolog)-like 1 RuvB-like 1 (E. coli) ruvB-like 1 Rvb1 RVB1 TATA binding protein interacting protein 49 kDa TIH1 TIP49a TIP49TAP54-alpha TIP60-associated protein 54-alpha

Research Areas for RUVBL1

Find related products by research area and learn more about each of the different research areas below.

Core ESC-Like Genes
Stem Cell Markers
Wnt Signaling Pathway