Proteasome 20S alpha 5 Products

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Bioinformatics

Entrez	26442 Mouse 29672 Rat 5686 Human
Uniprot	NP_002781 Human NP_002781.2 Human P28066 Human
Product By Gene ID	5686
Alternate Names	EC 3.4.25.1 FLJ42315 macropain subunit zeta Macropain zeta chain MGC117302 MGC125802 MGC125803 MGC125804 Multicatalytic endopeptidase complex zeta chain proteasome (prosome, macropain) subunit, alpha type, 5 proteasome alpha 5 subunit proteasome component 5 proteasome subunit alpha type-5 proteasome subunit zeta Proteasome zeta chain PSC5 ZETA

Research Areas for Proteasome 20S alpha 5

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Core ESC-Like Genes
Stem Cell Markers