PHD4/HIF Prolyl Hydroxylase 4 Products

Description

Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the post-translational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Bioinformatics

Uniprot	NM_177939 Human NP_808807.2 Human NP_808808.1 Human Q9NXG6 Human
Product By Gene ID	54681
Alternate Names	EC 1.14.11.- EGLN4 HIFPH4 HIF-PH4 HIF-prolyl hydroxylase 4 HPH-4 hypoxia-inducible factor prolyl 4-hydroxylase Hypoxia-inducible factor prolyl hydroxylase 4 P4H with transmembrane domain P4H-TMFLJ20262 PH4 hypoxia inducible factor prolyl 4 hydroxylase PH-4 PHD4 proline 4-hydroxylase prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) Prolyl hydroxlase domain-containing 4 transmembrane prolyl 4-hydroxylase

Research Areas for PHD4/HIF Prolyl Hydroxylase 4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Lipid and Metabolism