PDK-1 Products

Description

PDK-1 (3-phosphoinositide-dependent protein kinase, gene name PDPK1) is a 58 -68 kDa, 556 amino acid (aa) monomeric protein of the AGC serine/threonine kinase family. It is activated by phosphorylation in the presence of PtdIns(3,4,5) P3 or PtdIns(3,4) P2. Akt, S6 kinases, PKA and PKC-zeta are reported PDK-1 substrates. Through Akt, PDK-1 mediates many of the intracellular actions of insulin. Within the region used as an immunogen, human PDK-1 shares 98% aa identity with mouse and rat PDK-1. One reported isoform has an alternate start site at aa 50, while another lacking aa 238-263 is predicted to be catalytically inactive.

Bioinformatics

Uniprot	AAH39158 Human NM_002610 Human NP_002601 Human NP_002601.1 Human O15530 Human Q15118 Human
Product By Gene ID	5170
Alternate Names	3-phosphoinositide-dependent protein kinase 1 3-phosphoinositide-dependent protein kinase 2 pseudogene PDK1 PDPK2 PDPK2P PkB kinase like gene 1

Research Areas for PDK-1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Cytoskeleton Markers
Hypoxia
Lipid and Metabolism
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction