PAUF/ZG16B Products

Description

PAUF (pancreatic adenocarcinoma upregulated factor), gene name ZG16B (zymogen granule protein 16B), is a 156 amino acid, approximately 20-25 kDa secreted protein that is a member of the jacalin-binding lectin family. PAUF expression is thought to be restricted to primates, but the related ZG16P, which shares approximately 25% amino acid sequence identity, is more widely expressed. Human PAUF is overexpressed in pancreatic adenocarcinoma, binds Toll-like receptors TLR2 and TLR4, and inhibits CXCR4-dependent, TLR2-mediated NF-kB activation. It facilitates tumor growth, adhesiveness, and production of pro-tumorigenic cytokines.

Bioinformatics

Entrez	124220 Human
Uniprot	AAH09722 Human ENSP00000371715 Human Q96DA0 Human
Product By Gene ID	124220
Alternate Names	DKFZp762P2216 EC 3.1.2 EC 3.4.19.12 hTrabid TRABIDubiquitin thioesterase ZRANB1 TRAF-binding protein domain Zinc finger Ran-binding domain-containing protein 1 zinc finger, RAN-binding domain containing 1