nSMase Products

Description

Sphingomyelin is also present in all eukaryotic cell membranes, especially the plasma membrane, and is particularly concentrated in the nervous system because sphingomyelin is a major component of myelin, the fatty insulation wrapped around nerve cells by Schwann cells or oligodendrocytes. Multiple Sclerosis is a disease characterised by deterioration of the myelin sheath, leading to impairment of nervous conduction. nSMase (Neutral sphingomyelinase; Sphingomyelin phosphodiesterase 2) converts sphingomyelin to ceramide. Although widely expressed in all tissues examined, except the spleen, high enzymatic activity occurs only in the brain. Mice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity.

Bioinformatics

Uniprot	AAH00038 Human AAH00038.1 Human NP_003071 Human O60906 Human
Product By Gene ID	6610
Alternate Names	EC 3.1.4.12 ISC1 lyso-PAF-PLC Lyso-PAF-PLC Lyso-platelet-activating factor-phospholipase C Neutral sphingomyelinase nSMase NSMASE N-SMase NSMASE1 sphingomyelin phosphodiesterase 2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)

Research Areas for nSMase

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism