NOD1 Products

Description

Innate immunity is present in all animals and is the common mode of defense against microorganisms. It detects microorganisms by specific proteins called pattern-recognition molecules (PRMs) (reviewed in Werts et al. 2006). There is a limited set of PRMs in each animal genome, and it has been postulated that the PRMs were evolutionarily selected to detect conserved components or motifs of microorganisms called pathogen-associated molecular patterns (PAMPs). PAMPs are found in a wide range of microorganisms and recognition of PAMPs by PRMs activates inflammatory signaling pathways, thereby stimulating an immune response. NOD (nucleotide-binding oligomerization domain) proteins are a family of cytosolic proteins which have been implicated in innate recognition of bacteria, the induction of inflammatory responses, and the regulation of caspase activation and apoptosis. NOD1/CARD4 (caspase-recruitment domain 4 gene) is a PRM that recognizes specific peptidoglycan (PGN) components of bacterial cell walls (reviewed in Strober et al. 2006, and Inohara et al. 2003). NOD1 is expressed by cell types that are exposed to PGN under physiological conditions including antigen-presenting cells (APCs) such as macrophages and dendritic cells, and epithelial cells (reviewed in Strober et al. 2006). NOD1 is thought to play a role in the pathogenesis of human gastrointestinal disease and is associated with inflammatory bowel diseases and asthma. It is involved in host defense against Helicobacter pylori infection of the gastric mucosa, a chronic infection that can lead to peptic ulcers and gastric cancer. This antibody recognizes NOD1/CARD4. Human NOD1/CARD4 is a 953 amino acid protein.

Bioinformatics

Uniprot	AAH40339 Human AAH40339.1 Human NM_006092 Human NP_006083.1 Human
Product By Gene ID	10392
Alternate Names	CARD4NLR family, CARD domain containing 1 caspase recruitment domain family, member 4 Caspase recruitment domain-containing protein 4 CLR7.1 NLRC1 nucleotide-binding oligomerization domain containing 1 nucleotide-binding oligomerization domain, leucine rich repeat and CARD domaincontaining 1 nucleotide-binding oligomerization domain-containing protein 1

Research Areas for NOD1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Asthma
Autophagy
Immunology

Related NOD1 Blog Posts

Check out the latest blog posts on NOD1.

cIAP2 - balancing cell death and cell survival The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and ...    Read more.

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