Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ChIP
Host: Goat Polyclonal
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Species: Rb
Applications: ELISA
Species: Ch
Applications: ELISA
Species: Rt
Applications: ELISA
Description
Nuclear factor kappa beta (NFKB) is a transcription factor that is highly influenced by stress, free-radicals, UV light and hypoxia. Unsurprisingly, NFKB is essential for many human cancers, as it regulates the expression of many downstream proteins that regulate or modify cellular growth and development. NFKB effects on angiogenic pathways and reactive mechanisms to stress and damage are well established throughout literature. Atherosclerosis is partly attributed to the mis-regulation of NFKB in hypoxia. Arthritis is related to inflammation proteins regulated through NFKB. It also has been shown to be important in synapses in brain, leading to memory and cognitive ability or impairment. In all, NFKB is one of the fastest responding transcription factors in humans, and is likely to mediate many responsive events in diseases and injury recovery.
Bioinformatics
| Uniprot |
Human
Mouse
|
| Product By Gene ID |
4790 |
| Alternate Names |
- DNA-binding factor KBF1
- EBP-1
- NF-kappa-B
- NFKB1
- NFKB1
- NF-kB1
- NFKB-p105
- Nuclear factor NF-kappa-B p105 subunit
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
- p105
|
![Western Blot NFkB1/NFkB p105 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/NFkB1_AF2697_Western_Blot_5210.jpg)
![Chromatin Immunoprecipitation (ChIP) NFkB1/NFkB p105 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/NFkB1_AF2697_Chromatin_Immunoprecipitation_11230.jpg)
