NFkB p105/p50 Products

Description

NFkB is a transcription regulator that is activated by various intra and extra cellular stimuli such as cytokines, oxidant free radicals, ultraviolet irradiation, and bacterial or viral products. NFkB is a family of transcription factors that consists of homo and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL1 alpha and TNF alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422-540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth.

Bioinformatics

Uniprot	AAH51765 Human AAH51765.1 Human NM_003998 Human NP_003989 Human P19838 Human
Product By Gene ID	4790
Alternate Names	DKFZp686C01211 DNA binding factor KBF1 DNA-binding factor KBF1 EBP-1 KBF1 NF-kappaB NF-kappa-B NF-kappabeta NFKB-p105 NFKB-p50 nuclear factor kappa-B DNA binding subunit nuclear factor NF-kappa-B p105 subunit nuclear factor NF-kappa-B p50 subunit nuclear factor of kappa light polypeptide gene enhancer in B-cells 1MGC54151 p105 p50

Research Areas for NFkB p105/p50

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Biology
Diabetes Research
DNA Repair
Neurodegeneration
Neuroscience
Nucleotide Excision Repair
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related NFkB p105/p50 Blog Posts

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Nuclear Factor kappa B Signaling in the Immune System Nuclear Factor kappa B (NFkB) binds to the kappa-beta site of the immunoglobulin kappa light chain gene enhancer. Thus NFkB has become one of the widely studied transcription factors in innate and adaptive immune responses. The NFkB family is composed...    Read more.

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