NFAT5 Products

Description

The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.

Bioinformatics

Uniprot	NP_001106649 Human NP_006590 Human O94916 Human
Product By Gene ID	10725
Alternate Names	EC 3.6.1 EC 3.6.3.14 KIAA0827glutamine rich protein H65 NF-AT5NFAT-like protein 1 NFATL1 NFATZ nuclear factor of activated T-cells 5, tonicity-responsive OREBP osmotic response element-binding protein T-cell transcription factor NFAT5 TonE-binding protein TonEBP TONEBPnuclear factor of activated T-cells 5 Tonicity-responsive enhancer-binding protein

Research Areas for NFAT5

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Wnt Signaling Pathway