NALP12 Products

Description

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP12, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes. NALP12 may mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.

Bioinformatics

Uniprot	AAH28069 Human NM_144687 Human NP_653288 Human
Product By Gene ID	91662
Alternate Names	FCAS2 Monarch-1 NACHT, leucine rich repeat and PYD containing 12 NACHT, LRR and PYD domains-containing protein 12 NALP12LRR and PYD containing protein 12 NLR family, pyrin domain containing 12 nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 12 PYPAF7Monarch1 PYRIN-containing APAF1-like protein 7 Regulated by nitric oxide RNO2

Research Areas for NALP12

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Apoptosis

Related NALP12 Blog Posts

Check out the latest blog posts on NALP12.

Pyroptosis: Mechanisms mediating cell death and pro-inflammatory cytokine release By Victoria OsinskiPyroptosis is an inflammatory form of programmed cell death characterized by the release of pro-inflammatory cytokines IL-1 beta and IL-18.1,10 It is a process distinct from apoptosis and necrosis (T...    Read more.

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