MDM2/HDM2 Products

Description

MDM2 is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Bioinformatics

Entrez	17246 Mouse 4193 Human
Uniprot	ENSP00000258149 Human NM_002392 Human NP_002383 Human NP_002383.2 Human Q00987 Human
Product By Gene ID	4193
Alternate Names	ACTFS HDM2 HDMX MDM2 oncogene, E3 ubiquitin protein ligase

Research Areas for MDM2/HDM2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Cellular Markers
Hypoxia
Neuroscience
p53 Pathway
Phospho-Specific
Tumor Suppressors