LRRK2 Products

Description

LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

LRRK2 antibodies are useful tools for neurodegeneration research and certian kinase signaling pathway studies.

Bioinformatics

Entrez	120892 Human 300160 Rat 66725 Mouse
Uniprot	AAV63975 Human Q5S006 Mouse Q5S007 Human
Product By Gene ID	120892
Alternate Names	augmented in rheumatoid arthritis 17 AURA17 Dardarin DKFZp434H2111 EC 2.7.11.1 FLJ45829 leucine-rich repeat kinase 2 leucine-rich repeat serine/threonine-protein kinase 2 PARK8DARDARIN Parkinson disease (autosomal dominant) 8 RIPK7 ROCO2

Research Areas for LRRK2

Find related products by research area and learn more about each of the different research areas below.

Alzheimers Research
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Phospho-Specific
Protein Kinase

Related LRRK2 Blog Posts

Check out the latest blog posts on LRRK2.

The identification of dopaminergic neurons using Tyrosine Hydroxylase in Parkinson's research and LRRK2 Tyrosine hydroxylase (TH) is a crucial enzyme involved in the biosynthesis of dopamine, norepinephrine and epinephrine in the brain.  Specifically, TH catalyzes the conversion of l-tyrosine to l-dihydroxyphenylalanine (l-dopa).  The importance of t...    Read more.

The role of Parkin and autophagy in retinal pigment epithelial cell (RPE) degradation The root of Parkinson’s disease (PD) points to a poorly regulated electron transport chain leading to mitochondrial damage, where many proteins need to work cohesively to ensure proper function.  The two key players of this pathway are PINK1, ...    Read more.

Novus Antibodies Highlighted in Parkinson's Disease Research Identified almost two centuries ago, Parkinson's disease is a neurodegenerative disorder that afflicts an estimated 4-6 million worldwide (www.parkinsons.org). The prevalence of Parkinson's disease is expected to grow considerably as the average age o...    Read more.

Parkinson's Disease Infographic Parkinson's disease affects the nervous system which controls movement. Damage to the levels of dopamine in the brain impairs the ability to relay messages to parts of the body which control movement. While the exact cause of the disease is unknown, r...    Read more.

Read more LRRK2 related blogs.