Species: Hu, Mu, Rt, Bv, Fe, Fi, Ha, Pm
Applications: WB, Simple Western, Flow, ICC/IF, IHC, IP, B/N
Host: Mouse Monoclonal
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, Gp, Ha, Pm, Rb, Sh
Applications: WB, Simple Western, ELISA, Flow, ICC/IF, IHC, IP, MS
Host: Rat Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Func, PAGE
Description
Hsp73 is a normal cell constituent which is synthesized in increased abundance under adverse environmental circumstances, such as non-physiological temperatures or treatment with amino acid analogues (1). Data has shown a molecular mechanism for cytokine-mediated posttranscriptional regulation of Bim mRNA by Hsc70, which binds to AU-rich elements (AREs) in the 3'-untranslated region of specific mRNAs and enhances their stability. The RNA binding potential of Hsc70 is regulated by cochaperones including Bag-4 (also SODD), CHIP, Hip, and Hsp40 (2). Hsp73 protein expression was detected in the cytoplasm of melanoma cells in primary tumors and metastases. In primary melanomas, the proportion of Hsp73 protein expressing cells correlated with tumor thickness which was found to be statistically significant (3).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
3312 |
| Alternate Names |
- Heat shock 70 kDa protein 8
- heat shock 70kD protein 8
- heat shock 70kDa protein 8
- heat shock cognate 71 kDa protein
- heat shock cognate protein 54
- heat shock cognate protein, 71-kDa
- HSC54
- HSC70heat shock 70kd protein 10
- HSC71
- HSP71
- HSP73constitutive heat shock protein 70
- HSPA10
- LAP1
- lipopolysaccharide-associated protein 1
- LPS-associated protein 1
- MGC131511
- MGC29929
- NIP71
- N-myristoyltransferase inhibitor protein 71
|
Research Areas for HSPA8/HSC71/Hsc70
Find related products by research area and learn more about each of the different research areas below.
Membrane Trafficking and Chaperones
![Western Blot HSPA8/HSC71/Hsc70 Antibody (521503) [Unconjugated]](http://images.novusbio.com/fullsize2/HSPA8_MAB4148_Western_Blot_6155.jpg)
![Immunocytochemistry HSPA8/HSC71/Hsc70 Antibody (521503) [Unconjugated]](http://images.novusbio.com/fullsize2/HSPA8_MAB4148_Immunocytochemistry__Immunofluorescence_19004.jpg)
![Immunohistochemistry HSPA8/HSC71/Hsc70 Antibody (521503) [Unconjugated]](http://images.novusbio.com/fullsize2/HSPA8_MAB4148_Immunohistochemistry_20538.jpg)
![Simple Western HSPA8/HSC71/Hsc70 Antibody (521503) [Unconjugated]](http://images.novusbio.com/fullsize2/HSPA8_MAB4148_Simple_Western_20749.jpg)
