eNOS Products

Description

Nitric oxide (NO) is an inorganic, gaseous free radical that carries a variety of messages between cells. Vasorelaxation, neurotransmission and cytotoxicity can all be potentiated through cellular response to NO. NO production is mediated by members of the nitric oxide synthase (NOS) family. NOS catalyzes the oxidization of L-arginine to produce L-citrulline and NO. Two constitutive isoforms, brain or neuronal NOS (b or nNOS, type I) & endothelial cell NOS (eNOS, type III), and one inducible isoform (iNOS, type II), have been cloned. All NOS isoforms contain calmodulin, nicotinamide adenine dinucleotide phosphate (NADPH), flavin adenine dinucleotide (FAD), and flavin mononucleotide (FMN) binding domains. iNOS is found in a variety of cell types including macrophages, hepatocytes, synoviocytes, and smooth muscle cells. Cytokines such as interferon-gamma (IFN), tumor necrosis factor (TNF), interleukin-1 and -2, and lipopolysaccarides (LPS) cause an increase in iNOS mRNA, protein, and activity levels. Protein kinase C-stimulating agents exhibit the same effect on iNOS activity. After cytokine induction, iNOS exhibits a delayed activity response which is then followed by a significant increase in NO production over a long period of time.

Bioinformatics

Entrez	18127 Mouse 24600 Rat 4846 Human
Uniprot	AAH63294 Human AAH63294.1 Human AAH69465.1 Human NP_000594 Human P29474 Human
Product By Gene ID	4846
Alternate Names	Constitutive NOS EC 1.14.13.39 ECNOS Endothelial NOS endothelial eNOScNOS nitric oxide synthase 3 (endothelial cell) NOS type III NOSIII

Research Areas for eNOS

Find related products by research area and learn more about each of the different research areas below.

Cancer
HIF Target Genes
Hypoxia
Neuroscience
Neurotransmission
Phospho-Specific