Species: Hu, Mu, Rt
Applications: WB, ChIP, ICC/IF, IHC, IP, MS, KD, MS
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ChIP, ICC/IF, IHC, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Bv, Pm
Applications: WB, Simple Western, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Species: Hu
Applications: PAGE
Description
HIF prolyl hydroxylase 3 (HPH-3; PHD3; EGLN3) catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, hydroxylates HIF-1 alpha at Pro-564, and also hydroxylates HIF-2 alpha. PHD3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. EGLN3 may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. HIF prolyl hydroxylase 3 promotes cell death through a caspase-dependent mechanism.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
112399 |
| Alternate Names |
- EC 1.14.11
- EC 1.14.11.-
- EGL nine (C.elegans) homolog 3
- egl nine homolog 3 (C. elegans)
- egl nine homolog 3
- egl nine-like protein 3 isoform
- FLJ21620
- HIF prolyl hydroxylase 3
- HIFPH3 MGC125998
- HIF-PH3
- HIF-prolyl hydroxylase 3
- HPH-1
- HPH-3
- Hypoxia-inducible factor prolyl hydroxylase 3
- MGC125999
- pdh3
- PHD3
- Prolyl hydroxylase domain-containing protein 3
|
