Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt, Po, Pm
Applications: IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt(-)
Applications: ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: ELISA
Species: Rt
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: Bioactivity
Species: Hu
Applications: PAGE
Species: Hu
Applications: PAGE
Description
Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells. CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients.
Bioinformatics
| Entrez |
Human
Mouse
Rat
Bovine
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
1113 |
| Alternate Names |
- betagranin (N-terminal fragment of chromogranin A)
- CgA
- CGA
- chromogranin A (parathyroid secretory protein 1)
- chromogranin-A
- parathyroid secretory protein 1
- Pituitary secretory protein I
- SP-I
|
Related Chromogranin A Blog Posts
Check out the latest blog posts on Chromogranin A.
Beta Tubulin III and neurogenesis
Beta tubulin III, also known as Tuj-1, is a class III member of the beta tubulin protein family. Beta tubulins are one of two structural components that form our microtubule network. While general tubulins play a role in a wide range of cellular pr... Read more.
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Read more Chromogranin A related blogs.
![N/A Chromogranin A [Biotin]](http://images.novusbio.com/fullsize2/DATA_Chromogranin_A_DY909805_ELISA_2555.jpg)
![Binding Activity Chromogranin A [Unconjugated]](http://images.novusbio.com/fullsize2/10422-ch_recombinant-human-chromogranin-a-his-tag-protein-cf-binding-activity-1152020103812.jpg)
![SDS-PAGE Chromogranin A [Unconjugated]](http://images.novusbio.com/fullsize2/Chromogranin_A_10422CH_3054.jpg)