Chromogranin A Products

Description

Chromogranin A (CgA) is an 86 kDa protein that is the major member of the granin family of acidic secretory glycoproteins located in neuroendocrine cells. CgA is believed to play a role in targeting peptide hormones and neurotransmitters to granules of the regulated pathways and inhibit hormone and neurotransmitter release. Also, the widespread distribution of CgA has made the measurement of circulating immunoreactive CgA a valuable tool in the diagnosis of neuroendocrine neoplasia, and CgA immunohistochemistry can help to identify the neuroendocrine nature of tumors. The N-terminal domain of CgA inhibits tumor necrosis factor a (TNFa) induced gap formation in human umbilical venous endothelial cells. CgA levels which reflect neuroendocrine differentiation of prostatic carcinoma may have a diagnostic, therapeutic and prognostic role in the management of prostate cancer patients.

Bioinformatics

Entrez	1113 Human 12652 Mouse 24258 Rat 281070 Bovine
Uniprot	AAH06459 Human AAH06459.1 Human NM_001275 Human NP_001266 Human NP_001266.1 Human P10645 Human
Product By Gene ID	1113
Alternate Names	betagranin (N-terminal fragment of chromogranin A) CgA CGA chromogranin A (parathyroid secretory protein 1) chromogranin-A parathyroid secretory protein 1 Pituitary secretory protein I SP-I

Research Areas for Chromogranin A

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Neuronal Cell Markers

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