CDK4 Products

Description

Cdk4 is encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Bioinformatics

Entrez	1019 Human 12567 Mouse 94201 Rat
Uniprot	AAH03644 Human AAH05864 Human NP_000066 Human NP_000066.1 Human P11802 Human
Product By Gene ID	1019
Alternate Names	Cell division protein kinase 4 CMM3 cyclin-dependent kinase 4 EC 2.7.11 EC 2.7.11.22 melanoma cutaneous malignant, 3 MGC14458 PSK-J3cell division kinase 4

Research Areas for CDK4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Core ESC-Like Genes
mTOR Pathway
Protein Kinase
Stem Cell Markers