CDK4 Antibody

Cdk4 is encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publication 1 - 1 of 1.

Publication using NBP2-32288	Applications	Species
Jeon DG, Koh JS, Cho WH et al. Clinical outcome of low-grade central osteosarcoma and role of CDK4 and MDM2 immunohistochemistry as a diagnostic adjunct J Orthop Sci 2015-03-05 [PMID: 25740728] (IHC-P, Human) Details: CDK4 antibody used for IHC-P staining on samples from human low-grade central osteosarcoma /LCOS patients. IHC-P assay involved - endogenous peroxidase blocking with 3% H2O2 for 15 minutes, 20 minutes of antigen retrieval at 98C using 0.01 M citric acid pH 6.0 buffer, use of CDK4 antibody at 1:500 dilution with 1 hour RT incubation, DAB based kit detection system (Fig 2c).	IHC-P	Human

Array NBP2-32288

• CDK4 Antibodies
• CDK4 ELISA Kits
• CDK4 Lysate
• CDK4 Proteins