CD3 zeta Products

Description

CD3 (Cluster of Differentiation 3) is a complex of proteins that associates directly with the T cell antigen receptor (TCR). Antigen binding to the TCR leads to IL-2 secretion via activation of a tyrosine phosphorylation pathway and a phospholipase C (PLC) pathway, in turn activating protein kinase C. CD3 is composed of five invariant polypeptide chains that associate to form three dimers. The five invariant chains of CD3 are labeled gamma, delta, epsilon, zeta, and eta. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Loss of the zeta chain results in the synthesis of unstable TCRs. A decrease of CD3 zeta has been described in T cells from patients with cancer, lupus and chronic infectious diseases.

Bioinformatics

Entrez	12503 Mouse 22637 Mouse 25300 Rat 919 Human
Uniprot	AAH25703 Human NM_198053 Human NP_000725 Human NP_932170 Human NP_932170.1 Human P20963 Human
Product By Gene ID	919
Alternate Names	CD247 antigen CD247 antigen, zeta subunit CD247 molecule CD3H CD3Q CD3z antigen, zeta polypeptide (TiT3 complex) CD3ZT-cell receptor T3 zeta chain T3Z T-cell antigen receptor complex, zeta subunit of CD3 T-cell surface glycoprotein CD3 zeta chain TCRZCD3-ZETA

Research Areas for CD3 zeta

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
CD Markers
Cell Biology
Diabetes Research
Immunology
Phospho-Specific
Protein Kinase
Signal Transduction
Tyrosine Kinases