NCAM-1/CD56 Products

Description

NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.

Bioinformatics

Uniprot	AAH47244 Human AAH47244.1 Human NM_181351 Human NP_851996.2 Human P13591 Human P13592 Human
Product By Gene ID	4684
Alternate Names	CD56 / NCAM-1 CD56 antigen CD56 MSK39 N-CAM-1 NCAM-1 NCAMantigen recognized by monoclonal 5.1H11 neural cell adhesion molecule 1 neural cell adhesion molecule, NCAM

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