Tumor marker

Synaptonemal Complex Protein 1 (SCP1) is a novel tumor antigen that belongs to the growing family of cancer/testis antigens (CTA). SCP-1 is known to be selectively expressed during the meiotic prophase of spermatocytes and is involved in the pairing of homologous chromosomes during meiosis I. Investigation of a broad spectrum of normal and malignant tissues revealed that expression of SCP-1 transcripts and antigen selectively in a variety of neoplastic tissues and tumor cell lines.

Vimentin is a 57kDa type III intermediate filament (IF) protein that is the major cytoskeletal component of mesenchymal cells and the first to be expressed during cell differentiation. It plays a significant role in supporting and anchoring the position of the organelles in the cytosol and its dynamic nature is important for cell flexibility.  It is responsible for maintaining cell shape and cytoplasm integrity.

BRCA1, also known as breast cancer type 1 susceptibility protein and RING finger protein 53, belongs to a class of genes known as tumor suppressors. BRCA1 regulates cell growth and division, and is also involved in DNA repair.