Caspase 8 antibody

Programmed cell death via apoptosis is a key controlled physiological process instigated by the cell death receptor family, their ligands, and the caspase cysteine protease family. All caspases exist in a precursor form that contains a prodomain, and large and small catalytic subunits. A cleavage event adjacent to an aspartate liberates one large and one small subunit, which are now free to associate into an active a2b2 tetramer. Caspases are activated by triggers such as ligand-receptor interactions, growth factor deprivation, and cell function inhibitors.

Cell death via apoptosis is a fundamental cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. All caspases exist in a precursor form composed of a prodomain, and large and small catalytic subunits. Caspases require a cleavage adjacent to an aspartate to liberate one large and one small subunit, which can then associate into an a2b2 tetramer.

Caspase 7 (also known as CASP7, Mch3, ICE-LAP3, CMH-1) is a member of caspase family of cysteine proteases. It is an apoptosis-related cystein peptidase encoded by the CASP7 gene in humans. CASP7 homologous sequences have been identified in nearly all mammals. Similar to Caspase 3, Caspase-7 is an effector caspase and plays a key role in apoptotic execution.

Apoptosis is one of the best-characterized phenomena in cellular and molecular biology. Not only is it essential for successful development, but its deregulation also leads to a number of human diseases, most notably cancer.

The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.

Caspase 3 is a member of the cysteine-aspartic acid protease family and an important mediator of apoptosis. Caspase 3 antibody reagents have been used in cancer, Alzheimer's disease and stem cell research. A recent caspase 3 antibody ELISA study showed elevated levels of the p17 caspase 3 fragment were associated with myocardial infarction in humans.