Bax antibody

Dynamin-related Protein 1 (DRP1) is known to function in mitochondrial and peroxisomal division and mediate membrane fission through oligomerization into ring-like structure and sever the mitochondrial membrane, through a GTP hydrolysis-dependent mechanism.

Ku70 is a 70 kDa protein that was shown to be involved in multiple cellular pathways, mainly involving DNA repair and recombination. Among these are the non-homologus end repairs of DNA double strand breaks. Ku70 was first identified as an autoantigen in the serum of patients with Scleroderma Ploymyosistosis Syndrome (1).

Bax is a member of the Bcl-2 family; an extensive range of proteins which play key roles in apoptosis, or programmed cell death, by regulating outer mitochondrial membrane permeability. We at Novus Biologicals are one of the leading antibody suppliers for apoptosis research, with an extensive range of Bax antibody products.

Not everyone knows how antibodies influence animal life, so this article is, in part, a very brief introduction. Apoptosis is triggered by a variety of signals and takes place by one of several mechanisms. These involve cell surface receptors, cytokines, tumour necrosis factors, proteins such as Bcl-2, Bax and Apaf-1, the caspase cascade, and apoptosis-inducing factors.

Bcl-2 antibodies are used as markers for the Bcl-2 gene. Bcl-2 suppresses apoptosis (controlled cell death) by inhibiting caspase activity and controlling cell membrane permeability. It does this by forming mitochondrial pores on the outer membrane of the mitochondria. However, its exact mechanism of action is still not completely understood.