Ape1

AP-endonuclease (APE1/Ref-1) is an essential multifunctional protein involved in the repair of oxidative DNA damage as well as in transcriptional regulation in tumor cells. It functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions, and may also play a role in the epigenetic regulation of gene expression and the protection from granzymes-mediated cellular repair leading to cell death.

Apurinic/apyrimidinic (AP) endonuclease 1 (APE1) plays an important role in the DNA base excision repair pathway.

APE1 is involved in repairing oxidative DNA damages in vitro, regulates the redox of transcriptional factors, repairs AP sites in DNA, and is important for embryonic development in mice. Learn more about APE1 in our infographic below.

Novus Biologicals offers APE1 reagents for your research needs including:

An AP (apurinic/apyrimidinic) site, also known as an abasic site, is a region of DNA that is lacking a purine or pyrimidine base. This can occur spontaneously, or as a result of DNA damage. When DNA damage occurs, DNA repair pathways are activated.

APE1 (aka. HAP1, /Ref-1 or APEX) the mammalian ortholog of Escherichia coli Xth is a multifunctional protein possessing both DNA repair and transcriptional regulatory activity. APE1 acts essentially as master regulator of controlling cellular response to oxidative stress, and contributes to the genome stability (1).

Base excision repair (BER) is the most fundamental DNA repair mechanism, dealing with alterations arising in individual DNA bases during cellular metabolism. We at Novus Biologicals have a large BER antibody database, which has proven important in various cellular studies.