Originally identified as autoantigens from a Scleroderma Polymyositis Syndrome patient (1), the Ku protein family consists of nuclear proteins found in eukaryotes. Autoantibodies to both Ku subunits were subsequently found in other autoimmune diseases such as Systemic Lupus Erythematosus. The Ku heterodimer complex consists of Ku70 and Ku80 and is a very versatile protein that regulates a wide range of important and diverse cellular pathways such as DNA repair and DNA replication, telomere maintenance and telomere silencing, chromatin structure, V(D) J recombination, and Bax-mediated programmed cell death through apoptosis.
-Immunohistochemistry-Paraffin-NB100-1915-img0004.jpg "Immunohistochemistry-Paraffin: Ku70 Antibody")
Ku 70/80 is the central component of the non-homologous end joining pathway for double-stranded DNA break repair to maintain genome stability. Through the use of a Ku70 antibody, researchers have been able to show that Ku70 both associates Bax and has deubiquitin enzyme activity. These findings suggest more than a single activity for Ku70, but rather a dual role (2). Research on Ku70/80 distribution, localization, and therapeutic potential was done using a Ku70 antibody in glioblastoma samples, and found that the heterodimer is uniquely expressed on the plasma membrane and therefore could be a target for immunotherapy (3).
Novus Biologicals offers Ku70 reagents for your research needs including:
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