beta-Arrestin 1 Antibody

beta-arrestin-1 is a member of the arrestin family that regulates beta-adrenergic receptor function. Beta-arrestins seem to mediate the desensitization and internalization of G protein-coupled receptors (1). Phosphorylation by Erk1/2 at Serine 412 of the C-terminus is necessary to activate beta-arrestin-1 (2). Expanded roles for beta-arrestin-1 have been studied. Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases (3,4).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-64749

• beta-Arrestin 1 Antibodies
• beta-Arrestin 1 ELISA Kit
• beta-Arrestin 1 Lysate
• beta-Arrestin 1 Proteins