XRCC1 Products

Description

XRCC1 (X-ray cross complementing factor-1) is involved in DNA base excision repair. XRCC1 is a 70kDa protein that has been shown to be physically associated with other DNA repair enzymes, including poly (ADP-ribose) polymerase (PARP), DNA Ligase III and DNA polymerase beta. XRCC1 contains a BRCT domain (for BRCA1 carboxyl terminus) which was originally found in the tumor suppressor protein BRCA1. Recently, the BRCT domain has been shown to mediate the protein-protein interaction of XRCC1 and DNA Ligase III-a.

Bioinformatics

Entrez	7515 Human 84495 Rat
Uniprot	AAH23593.1 Human NM_006297 Human NP_006288 Human P18887 Human
Product By Gene ID	7515
Alternate Names	DNA repair protein XRCC1 RCC X-ray repair complementing defective repair in Chinese hamster cells 1 X-ray repair cross-complementing protein 1 X-ray-repair, complementing defective, repair in Chinese hamster

Research Areas for XRCC1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Base Excision Repair
Cancer
DNA Repair
Homologous Recombination
Phospho-Specific
Tumor Suppressors

Related XRCC1 Blog Posts

Check out the latest blog posts on XRCC1.

PARP Antibody Assays aid both Apoptosis and Cancer Research The PARP (Poly(ADP-ribose) polymerase) protein is a zinc-dependant nuclear enzyme whose main role is to detect and repair DNA single-strand breaks (SSB). However, PARP antibody research has revealed there are at least 17 PARP proteins, which also play...    Read more.

Read more XRCC1 related blogs.