V alpha 24 J alpha 18 TCR Antibody (6B11) - BSA Free

The 6B11 monoclonal antibody reacts with an epitope of the CDR3 formed by the germ-line configuration of the V alpha 24 and J alpha 18 of the TCR alpha locus, which results in the expression of an invariant T-cell receptor (TCR) expressed by invariant NK T cells (iNKT). This TCR is homologous to the murine V alpha 14 J alpha 18. This TCR alpha chain pairs with a restricted set of rearranged TCR beta chains, with V beta 11 being the most prominent in humans. NK T cells are restricted by the CD1d molecule and are activated by a CD1d-resented glycolipid ligand, which results in the rapid production of IL-4, IL-13 and IFN gamma. Although iNKT cells have NK-like cytolyticactivity, they are considered regulators of immune responses because they rapidly produce large amounts of both Th1 and Th2 cytokines in autoimmune disease, infectious disease, and cancer. The number of iNKT cells present in peripheral blood of normal humans shows considerable variability ranging from 0.01-1% of total peripheral T cells.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: FLOW, ICC/IF, IHC-Fr.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using NBP2-00267	Applications	Species
Landoni E, Smith C, Fuca G, et al. Landoni E, Smith C, Fuca G, et al. Cancer Immunol Res. 2020-01-08 [PMID: 31719055] (ICC/IF, Human)	ICC/IF	Human
van der Vliet HJ, Koon HB, Yue SC et al. Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin Cancer Res. 2007-04-01 [PMID: 17404092] (FLOW, Human)	FLOW	Human
Kis J, Engelmann P, Farkas K et al. Reduced CD4+ subset and Th1 bias of the human iNKT cells in Type 1 diabetes mellitus. J Leukoc Biol. 2007-03-01 [PMID: 17151140]
Akbari O. The role of iNKT cells in development of bronchial asthma: a translational approach from animal models to human. Allergy. 2006-08-01 [PMID: 16867051] (ICC/IF, FLOW, Human)	ICC/IF, FLOW	Human
Pham-Thi N, de Blic J, Leite-de-Moraes MC. Invariant natural killer T cells in bronchial asthma. N Engl J Med. 2006-06-15 [PMID: 16775881] (FLOW, Human)	FLOW	Human
Berzins SP, Smyth MJ, Godfrey DI. Working with NKT cells--pitfalls and practicalities. Curr Opin Immunol. 2005-08-01 [PMID: 15963710] (IHC-Fr, FLOW, Human)	IHC-Fr, FLOW	Human
Bollyky PL, Wilson SB. CD1d-restricted T-cell subsets and dendritic cell function in autoimmunity. Immunol Cell Biol. 2004-06-01 [PMID: 15186262] (FLOW, Human)	FLOW	Human
Fuss IJ, Heller F, Boirivant M et al. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest. 2004-05-01 [PMID: 15146247] (FLOW, Human)	FLOW	Human
Metelitsa LS, Wu HW, Wang H et al. Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J Exp Med. 2004-05-03 [PMID: 15123743] (FLOW, IHC-Fr, Human)	FLOW, IHC-Fr	Human
Levy O, Orange JS, Hibberd P et al. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis. 2003-10-01 [PMID: 14513412] (FLOW, Human)	FLOW	Human
Hou R, Goloubeva O, Neuberg DS et al. Interleukin-12 and interleukin-2-induced invariant natural killer T-cell cytokine secretion and perforin expression independent of T-cell receptor activation. Immunology. 2003-09-01 [PMID: 12941138] (FLOW, Human)	FLOW	Human
Boyson JE, Rybalov B, Koopman LA et al. CD1d and invariant NKT cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A. 2002-10-15 [PMID: 12368486] (FLOW, Human)	FLOW	Human
Show All 12 Publications. Collapse Publications.

Array NBP2-00267

• V alpha 24 J alpha 18 TCR Antibodies