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Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

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SDS-Page: Recombinant Mouse TRANCE/TNFSF11/RANK L Protein [NBP2-77509] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain. Molecular Weight: 17.9 kDa (160aa) confirmed by MALDI-TOF.
SDS-Page: Recombinant Mouse TRANCE/TNFSF11/RANK L Protein [NBP2-77509] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain. Molecular Weight: 17.9 kDa (160aa) confirmed by MALDI-TOF.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

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Recombinant Mouse TRANCE/TNFSF11/RANK L Protein Summary

Description
A recombinant protein with a un-tagged and corresponding to the amino acids 158-316 of Mouse TRANCE/RANK L/TNFSF11.

Source: E.coli

Amino Acid Sequence: MKPEAQPFAH LTINAASIPS GSHKVTLSSW YHDRGWAKIS NMTLSNGKLR VNQDGFYYLY ANICFRHHET SGSVPTDYLQ LMVYVVKTSI KIPSSHNLMK GGSTKNWSGN SEFHFYSINV GGFFKLRAGE EISIQVSNPS LLDPDQDATY FGAFKVQDID
Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
TNFSF11
Purity
>90%, by SDS-PAGE
Endotoxin Note
< 1.0 EU per 1ug of protein (determined by LAL method)

Applications/Dilutions

Dilutions
  • SDS-Page
Theoretical MW
17.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.5), 0.1M NaCl
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Mouse TRANCE/TNFSF11/RANK L Protein

  • CD254 antigen
  • CD254
  • ODF
  • OPGL
  • OPGLOPTB2
  • Osteoclast differentiation factor
  • Osteoprotegerin ligand
  • RANK L
  • RANKL
  • RANKLreceptor activator of nuclear factor kappa B ligand
  • Receptor activator of nuclear factor kappa-B ligand
  • sOdf
  • TNF-related activation-induced cytokine
  • TNFSF11
  • TRANCE
  • TRANCEODFhRANKL2
  • tumor necrosis factor (ligand) superfamily, member 11
  • tumor necrosis factor ligand superfamily member 11

Background

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Recombinant Mouse
TRANCE/TNFSF11/RANK L ...
NBP2-77509
Recombinant Mouse TRANCE/TNFSF11/RANK L Protein
Species: Mu
Applications: PAGE

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Bioinformatics

Gene Symbol TNFSF11