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TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

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Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) [NB110-93504] - Analysis of Rat Hippocampal lysate showing specific immunolabeling of the -50k and the -58k TR-a2 protein.
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) [NB110-93504] - Analysis of Rat Hippocampal lysate showing specific immunolabeling of the -50k and the -58k TR-a2 protein.

Product Details

Summary
Reactivity Hu, Rt, Mu, Ca, PmSpecies Glossary
Applications WB
Clone
2103
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103) Summary

Immunogen
Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P10827
Specificity
Specific for endogenous levels of the ~50 kDa TR-alpha 1 and the ~58 kDa TR-alpha 2 proteins.
Predicted Species
Mouse (100%), Canine (100%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
THRA
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Western Blot 1:1000
Theoretical MW
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

It is anticipated that the antibody will react with canine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
Preservative
No Preservative
Purity
Protein G purified

Alternate Names for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (2103)

  • AR7
  • c-ERBA-1
  • c-erbA-alpha
  • EAR7
  • EAR-7
  • EAR-7.1/EAR-7.2
  • ERBA
  • ERBA1thyroid hormone receptor, alpha (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog)
  • ERBA-related 7
  • MGC000261
  • MGC43240
  • NR1A 1
  • NR1A1
  • NR1A1THRA3
  • Nuclear receptor subfamily 1 group A member 1
  • THRA
  • THRA1ERB-T-1
  • THRA2
  • thyroid hormone receptor alpha
  • thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a)oncogene homolog, avian)
  • TR alpha
  • triiodothyronine receptor
  • v-ErbA1
  • V-erbA-related protein 7

Background

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TR alpha1, TR alpha2, TR beta1 and TR beta2. TR alpha1, TR beta1 and TR beta2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol THRA
Entrez
Uniprot