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Tenascin C Antibody (4C8MS) [DyLight 488]

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Product Details

Summary
Reactivity Hu, Mu, Rt, FeSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC, CyTOF-ready
Clone
4C8MS
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-68136AF350
Alexa Fluor 405
NB110-68136AF405
Alexa Fluor 488
NB110-68136AF488
Alexa Fluor 532
NB110-68136AF532
Alexa Fluor 594
NB110-68136AF594
Alexa Fluor 647
NB110-68136AF647
Alexa Fluor 700
NB110-68136AF700
Alexa Fluor 750
NB110-68136AF750
Allophycocyanin
NB110-68136APC
Allophycocyanin/Cy7
NB110-68136APCCY7
Biotin
NB110-68136B
CoraFluor 1
NB110-68136CL1
DyLight 350
NB110-68136UV
DyLight 405
NB110-68136V
DyLight 550
NB110-68136R
DyLight 594
NB110-68136DL594
DyLight 650
NB110-68136C
DyLight 680
NB110-68136FR
DyLight 755
NB110-68136IR
FITC
NB110-68136F
HRP
NB110-68136H
Janelia Fluor 525
NB110-68136JF525
Janelia Fluor 549
NB110-68136JF549
Janelia Fluor 646
NB110-68136JF646
Janelia Fluor 669
NB110-68136JF669
PE
NB110-68136PE
PE/Atto594
NB110-68136PEATT594
PE/Cy5.5
NB110-68136PECY55
PE/Cy7
NB110-68136PECY7
Unconjugated
NB110-68136
mFluor Violet 450 SE
NB110-68136MFV450
mFluor Violet 500 SE
NB110-68136MFV500
mFluor Violet 610 SE
NB110-68136MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB110-68136
BSA Free
NB110-68136SS
Azide and BSA Free
NBP2-80973
BSA Free
NB110-68136
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Tenascin C Antibody (4C8MS) [DyLight 488] Summary

Immunogen
Recombinant human Tenascin C [Swiss-Prot# P24821].
Localization
Secreted > extracellular space > extracellular matrix
Specificity
NB110-68136 specifically reacts with Domain B on FNIII repeats of Tenascin C.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TNC
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • CyTOF-ready
  • ELISA
  • Flow (Intracellular)
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Feline reactivity reported in customer review.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Tenascin C Antibody (4C8MS) [DyLight 488]

  • 150-225
  • Cytotactin
  • Glioma-associated-extracellular matrix antigen
  • GMEM
  • GP 150-225
  • hexabrachion (tenascin C, cytotactin)
  • hexabrachion (tenascin)
  • Hexabrachion
  • HXB
  • HXBcytotactin
  • JI
  • MGC167029
  • Myotendinous antigen
  • neuronectin
  • Tenascin C
  • Tenascin J1
  • tenascin
  • tenascin-C isoform 14/AD1/16
  • Tenascin-C
  • TNC
  • TN-C
  • TNGP

Background

In most tissues of adults, tenascin C is rarely present at significant levels. However, in developing tissues, or tissues experiencing a fast rate of growth, tenascin C is upregulated. This effect is particularly evident when this extracellular matrix glycoprotein is found in abundance in tissues responding to injury or infection. When muscular pH is increased, tenascin C production also increases. Prostate smooth muscle cells produce extra tenascin C when responding to LPS infection. In fibrosis and stenosis, tenascin C expression levels are markedly increased, and the protein seems to function as a mobilizer of immune cells responding to tissue damage and repair. In COPD, likewise, tenascin C expression is increased and is associated with cells attempting to repair damage within the lung. In short, tenascin C can be expected to be found in adult tissues only when associated with tissue damage and repair efforts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Tenascin C Antibody (NB110-68136G). (Showing 1 - 1 of 1 FAQ).

  1. One of our clients is looking for antibodies against tenascin C and fibronectin that could be used for FFPE rat tissues. These antibodies should exclusively recognize tenascin C and fibronectin and do not cross react with each other. Can you inform me if you have these antibodies?
    • Here is a link to Tenascin C antibodies we have validated in rat tissues for IHC-P Here are antibodies we have validated in fibronectin in rat tissues for IHC-P

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TNC