STK33 Antibody [FITC]

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

STK33 (serine/threonine-protein kinase 33) belongs to Ca2+/calmodulin-dependent kinase family (CAMK) and mainly play role in the dynamic behavior of intermediate filament cytoskeleton by phosphorylation of vimentin. STK33 undergoes compulsory autophosphorylation and then phosphorylates vimentin in vitro specifically in the vimentin head domain. STK33 and vimentin have been shown to be interacting protein partners in vivo also and STK33 has been proposed to be involved in the dynamics of intermediate filament assembly/disassembly via vimentin phosphorylation. Downregulation of STK33 by RNAi or inhibition of its kinase activity by overexpression of a kinase dead (KD) K145M STK33 protein conferred a lethal phenotype to mutant KRAS cell lines. Suppression of STK33 expression by either method resulted in inhibition of p70S6K and RPS6 phosphorylation but had no effect on the phosphorylation of AKT, ERK1/2, or mTOR, suggesting that STK33 is downstream from these nodes, but upstream from p70S6K.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array NBP1-54156F

• STK33 Antibodies
• STK33 Lysate
• STK33 Proteins