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SARS-CoV-2 Membrane Protein Antibody [Alexa Fluor® 350]

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Product Details

Summary
Reactivity V, VSpecies Glossary
Applications WB, ELISA, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Alexa Fluor 350

Order Details

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SARS-CoV-2 Membrane Protein Antibody [Alexa Fluor® 350] Summary

Immunogen
This antibody was raised against a peptide corresponding to 15 amino acids near the carboxyl terminus of SARS-CoV-2 (COVID-19) Membrane protein. The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19) Membrane protein.
Predicted Species
SARS-CoV (93%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
M
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Immunohistochemistry
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

0

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SARS-CoV-2 Membrane Protein Antibody [Alexa Fluor® 350]

  • 2019-nCoV M protein
  • 2019-nCoV Membrane Protein
  • COVID-19 E1 Glycoprotein
  • COVID-19 Matrix glycoprotein
  • COVID-19 Membrane glycoprotein
  • COVID-19 Membrane
  • E1 glycoprotein
  • Human coronavirus Membrane Protein
  • Matrix glycoprotein
  • Membrane glycoprotein
  • Membrane Protein
  • SARS-CoV-2 E1 Glycoprotein
  • SARS-CoV-2 M Protein
  • SARS-CoV-2 Matrix glycoprotein
  • SARS-CoV-2 Membrane glycoprotein
  • SARSCoV2 Membrane Protein
  • SARS-CoV-2
  • Severe Acute Respiratory Syndrome Coronavirus 2

Background

The SARS-CoV-2 Membrane protein is one of the four major structural proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 (1). The membrane protein is the most abundant of the four structural proteins, which also includes the envelope protein, spike protein, and nucleocapsid protein (1,2). The membrane protein is synthesized as a 222 amino acid protein with a theoretical molecular weight of 25.1 kDa (2,3). Furthermore, the membrane protein of SARS-CoV-2 has 90.5% sequence identity and 98.2% sequence similarity to that of the membrane protein of SARS-CoV (2). Structurally, the membrane protein is a type III transmembrane glycoprotein containing a glycosylated N-terminal ectodomain, three transmembrane domains, and a large C-terminal that extends into the viral particle (2,4). The membrane protein exists as a dimer and is either in long or compact conformation, which contributes to the curvature of the viral membrane (2,4). The main functions of the membrane protein are for viral assembly and contributing to the shape and structural integrity of the viral envelope (1,2). Additional functions show a role in inducing apoptosis as well as interactions with the spike and nucleocapsid proteins (1,2). The membrane-spike protein interaction is required for maintaining the spike protein within the ER-Golgi intermediate compartment (1). The membrane protein binding with the nucleocapsid protein is responsible for nucleocapsid stabilization and viral assembly (1).

References

1. Malik Y. A. (2020). Properties of Coronavirus and SARS-CoV-2. The Malaysian Journal of Pathology.

2. Yoshimoto F. K. (2020). The Proteins of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2 or n-COV19), the Cause of COVID-19. The Protein Journal. https://doi.org/10.1007/s10930-020-09901-4

3. Uniprot (P0DTC5)

4. J Alsaadi, E. A., & Jones, I. M. (2019). Membrane binding proteins of coronaviruses. Future Virology. https://doi.org/10.2217/fvl-2018-0144

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for SARS-CoV-2 Membrane Protein Antibody (NBP3-07059AF350) (0)

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Secondary Antibodies

 

Isotype Controls

Additional SARS-CoV-2 Membrane Protein Products

Blogs on SARS-CoV-2 Membrane Protein.

Early T cell response is associated with mild COVID-19 and rapid SARS-CoV-2 clearance
Jamshed Arslan, Pharm D, PhD SARS-CoV-2 induces both humoral and cellular immunity. A vaccine or natural infection invokes SARS-CoV-2-specific humoral components (antibodies from activated B cells) and cellular resp...  Read full blog post.

SARS-CoV-2 Vaccine Targets: The Present and Future of COVID-19
Jamshed Arslan, Pharm D, PhD Current approved and candidate vaccinesSARS-CoV-2 spike (S) protein is the main target of COVID-19 vaccines. Pfizer/BioNTech and Moderna vaccines are RNA-based vaccines while Oxford-Ast...  Read full blog post.

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Bioinformatics

Gene Symbol M