Recombinant Rat CTGF Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Connective Tissue Growth Factor (CTGF), also known as CCN2, is a 36-38 kDa member of the CCN (CYR61/CTGF/NOV) family of secreted matricellular proteins (1). Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain (2). Rat CTGF shares 94% and 99% amino acid (aa) sequence identity with human and mouse CTGF, respectively. CTGF promotes cell adhesion through interactions with a range of cell surface molecules including heparan sulfate proteoglycans (HSPG), LRPAP, and Integrins alpha M, alpha V beta 3, alpha 6 beta 1, alpha IIb beta 3 (3-7). It also binds to and regulates signaling through the Wnt receptors LRP6 and Frizzled-8 and the NGF receptors TrkA and NGF R (8, 9). In addition, CTGF binds directly to BMP-4, TGF-beta 1, TGF-beta 2, and VEGF 165 (10, 11). It blocks BMP-4 and VEGF induced responses but enhances TGF-beta induced responses (10-13). Within VEGF complexes, CTGF can be degraded by a variety of proteases, resulting in restoration of angiogenic activity (11). CTGF promotes fibroblast differentiation from mesenchymal stem cells and their production of type I Collagen and Tenascin C (5, 14). It promotes chondrocyte proliferation and cartilage matrix synthesis (15-17). CTGF is expressed in vascular mural and endothelial cells (EC) during development and promotes pericyte-EC association and angiogenesis (2, 17, 18, 19). It is expressed in the cerebral cortex and olfactory bulb and plays an important role in nervous system development (8, 12).

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 3 applications: Bioassay, In Vivo, In vivo assay.

Showing Publications 1 - 7 of 7.

Publications using 9237-CT	Applications	Species
Shimizu, M;Yoshimatsu, G;Morita, Y;Tanaka, T;Sakata, N;Tagashira, H;Wada, H;Kodama, S; Rescue of murine hind limb ischemia via angiogenesis and lymphangiogenesis promoted by cellular communication network factor 2 Scientific reports 2023-11-16 [PMID: 37973852] (In vivo assay, Mouse)	In vivo assay	Mouse
Sun, J;Zhang, H;Liu, D;Liu, W;Du, J;Wen, D;Li, L;Zhang, A;Jiang, J;Zeng, L; CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s Respiratory research 2023-09-23 [PMID: 37741976] (In Vivo, Mouse)	In Vivo	Mouse
E Manieri, G Tie, D Seruggia, S Madha, A Maglieri, K Huang, Y Fujiwara, K Zhang, S Orkin, R He, N McCarthy, RA Shivdasani Structure, signals, and cellular elements of the mouse gastric mesenchymal niche bioRxiv : the preprint server for biology, 2023-02-24;0(0):. 2023-02-24 [PMID: 36798304] (Bioassay, Mouse)	Bioassay	Mouse
Z Yuan, J Wang, H Zhang, Y Chai, Y Xu, Y Miao, Z Yuan, L Zhang, Z Jiang, Q Yu Glycocholic acid aggravates liver fibrosis by promoting the up-regulation of connective tissue growth factor in hepatocytes Cellular Signalling, 2022-10-29;101(0):110508. 2022-10-29 [PMID: 36341984] (Bioassay, Rat)	Bioassay	Rat
S Hashiguchi, T Tanaka, R Mano, S Kondo, S Kodama CCN2-induced lymphangiogenesis is mediated by the integrin alphavbeta5-ERK pathway and regulated by DUSP6 Scientific Reports, 2022-01-18;12(1):926. 2022-01-18 [PMID: 35042954] (Bioassay, In Vivo, Mouse)	Bioassay, In Vivo	Mouse
B Sun, M Lian, Y Han, X Mo, W Jiang, Z Qiao, K Dai A 3D-Bioprinted dual growth factor-releasing intervertebral disc scaffold induces nucleus pulposus and annulus fibrosus reconstruction Bioact Mater, 2020-08-14;6(1):179-190. 2020-08-14 [PMID: 32913927] (Bioassay, Rat)	Bioassay	Rat
AR Hwang, JO Nam, YJ Kang Fluvastatin inhibits advanced glycation end products-induced proliferation, migration, and extracellular matrix accumulation in vascular smooth muscle cells by targeting connective tissue growth factor Korean J. Physiol. Pharmacol., 2018-02-23;22(2):193-201. 2018-02-23 [PMID: 29520172] (Bioassay, Rat)	Bioassay	Rat

Array 9237-CT

• CTGF/CCN2 Antibodies
• CTGF/CCN2 ELISA Kits
• CTGF/CCN2 Lysate
• CTGF/CCN2 Proteins
• CTGF/CCN2 Proteins and Enzymes
• CTGF/CCN2 ELISA